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PROGRESS TOWARDS TARGETING DISEASE PROPHYLAXIS IN EUROPEAN FISH FARMING (TARGETFISH)

Geert Wiegertjes1*, Niel Lorenzen2, Chris J. Secombes3, Bertrand Collet4, Uwe Fischer5, Carolina Tafalla6, David Parra7, Giuseppe Scapigliati8, Pierre Boudinot9, Oystein Evensen10, Hetron M. Munang'Andu11*, Sandra Adams12, Anna Toffan13, Kurt Buchmann14, Tomas Vesely15, Lior David16, Victoriano Mulero17, Patrick Smith18, Vidar Aspehaug19, Kirsten Engell-Sørensen20, Juri Sober21, Tim Willis22, Torben Rød23, Maria Flores24, Ansgar Stratmann25, Panos Christofilogiannis26, Jaime Tobar27, Niels H. Henriksen28, Trygve Sigholt29 and Ana De Las Heras30
  • 1 Wageningen University, Netherlands
  • 2 Technical University of Denmark, Denmark
  • 3 University Court of Aberdeen, United Kingdom
  • 4 Marine Scotland, United Kingdom
  • 5 Frieddrich Loeffler Institut, Germany
  • 6 Instituto Nacional De Investigation Y Technologia Agraria Alimentaria, INIA, Spain
  • 7 Universitat Autonoma de Barcelona, Spain
  • 8 Tuscia University, UTUS, Spain
  • 9 Institut National National de la Recherche Agronomique, INRA, France
  • 10 Norwegian University of Life Sciences, BASAM, Norway
  • 11 Norwegian University of Life Sciences, BASAM, Norway
  • 12 University of Sterling, United Kingdom
  • 13 The Instituto Zooprofilattic Sperimentale Dell Venezie, (IZSVE), Italy
  • 14 University of Copenhagen, Denmark
  • 15 Veterinary Research Institute, Austria
  • 16 The Hebrew University of Jerusalem, (HUJI), Israel
  • 17 Universidad de Murcia, UMU, Spain
  • 18 Tethy Aquaculture, United Kingdom
  • 19 Patogen Analyse AS, Norway
  • 20 FishLab, Denmark
  • 21 NAXO LTD, Estonia
  • 22 Ridgeway Biological Ltds, United Kingdom
  • 23 Rossi International, (ROS), Denmark
  • 24 Ingeniatrics tecnologias SL, Spain
  • 25 Industrial Biotechnology, Germany
  • 26 PANAgiotis christofilogiannis IO Anna Tavlva O.E Aquark, Greece
  • 27 Centrovet, Chile
  • 28 Dansk AKvkakultur (DA), Denmark
  • 29 Biomar, Norway
  • 30 Bioorganic Research and Services, S.A. Bionatrius (BNT), Spain

TargetFish is a large collaborative project funded by the European Commission under the 7th Framework Programme for Research and Technological Development (FP7) of the European Union (Grant Agreement 311993). The project will run for 5 years, started in November 2012 and thus is approximately halfway. TargetFish brings together a large number of leading European research groups (RTD) that are experts on fish pathology and immunology and small-to-medium enterprises (SME) as well as some larger industries from the Biotech and Veterinary sectors, which all share a common interest and experience: vaccination of fish. To achieve this challenging task, we brought together approximately 30 partners from 10 EU member states, two associated countries and one International Cooperation Partner Country (Chile). In this large multidisciplinary consortium an approximate equal number of RTD and SME partners cooperate closely while keeping an intensive communication with the vaccine and nutrition industries. The main objectives of the project are to: 1) generate knowledge by studying antigens and adjuvants for different routes of administration while analyzing the underpinning protective immune mechanisms; 2) validate this knowledge with response assays for monitoring vaccine efficacy and safety, including issues associated with DNA vaccines; 3) approach implementation of prototype vaccines shortening the route to exploitation and 4) optimize vaccination strategies in order to obtain maximum protection in different sizes of fish. At present, progress has been made in particular with regard to main objectives 1-3. The vaccine delivery systems under investigation include oral routes of administration using, for example, alginate microencapsulation and MicroMatrixTM technologies. TargetFish also focuses on investigating mucosal vaccination routes and associated immunity and in developing antigens and adjuvants specifically suited for mucosal delivery. Most fish vaccines on the market are delivered by injection, being this a labour-intensive, expensive method that provokes stress in the fish. Mucosal vaccination routes (immersion or oral) would certainly be more desirable.

Acknowledgements

The Project is funded by the European Commission 7th Framework programme grant agreement number 311993.

Keywords: Vaccines, targetfifsh, aquacutlure, immerson, Oral, mucosal immunity

Conference: AquaEpi I - 2016, Oslo, Norway, 20 Sep - 22 Sep, 2016.

Presentation Type: Poster

Topic: Aquatic Animal Epidemiology

Citation: Wiegertjes G, Lorenzen N, Secombes CJ, Collet B, Fischer U, Tafalla C, Parra D, Scapigliati G, Boudinot P, Evensen O, Munang'Andu HM, Adams S, Toffan A, Buchmann K, Vesely T, David L, Mulero V, Smith P, Aspehaug V, Engell-Sørensen K, Sober J, Willis T, Rød T, Flores M, Stratmann A, Christofilogiannis P, Tobar J, Henriksen NH, Sigholt T and De Las Heras A (2016). PROGRESS TOWARDS TARGETING DISEASE PROPHYLAXIS IN EUROPEAN FISH FARMING (TARGETFISH). Front. Vet. Sci. Conference Abstract: AquaEpi I - 2016. doi: 10.3389/conf.FVETS.2016.02.00013

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Received: 30 May 2016; Published Online: 14 Sep 2016.

* Correspondence:
Prof. Geert Wiegertjes, Wageningen University, Wageningen, Netherlands, geert.wiegertjes@wur.nl
Dr. Hetron M Munang'Andu, Norwegian University of Life Sciences, BASAM, Oslo, NO-0033, Norway, hetron.m.munangandu@nord.no