A Pilot Study on the Association between SLCO1B1 rs4363657 Polymorphism and Muscle Adverse Events in Adults with Newly Diagnosed Dyslipidaemia who were Prescribed a Statin: The Malaysian Primary Health Care Cohort
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1
Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Malaysia
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2
Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Department of Family Medicine, Malaysia
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3
Department of Community Health, Faculty of Medicine and Health Sciences, Putra Malaysia University, Malaysia
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4
Department of Medicine, Faculty of Medicine and Health Sciences, University Putra Malaysia, Malaysia
Background
Statin, the first-line treatment for dyslipidaemia, may have suboptimal adherence due to its associated muscle adverse events. This data however, remains limited, due to under-reporting, mis/underdiagnoses or statin-associated muscle adverse events are generally rare. The aim of this study is to determine the association of serum creatine kinase (CK) and rs4363657 polymorphism of SLCO1B1 gene with statin-associated muscle adverse events among dyslipidaemia subjects.
Methods
This was a prospective cohort study at government health clinics involving newly diagnosed adults with dyslipidaemia. Muscle adverse events were recorded based on the patient’s complaint after a month on statin (lovastatin or simvastatin). Biochemical analyses including CK, fasting lipid profile, apo A1, apo B were taken at baseline and follow-up. Genetic profiling was performed for rs4363657 polymorphism of SLCO1B1 gene.
Results
A total of 118 subjects participated. Majority were Malay (72%) males (61%) with a mean age of 49 ± 12.2 years old and prescribed lovastatin (61.9%). There was a significant association between types of statin and muscle adverse events (p = 0.0327); frequency of muscle adverse events was higher with lovastatin (15.2%). No significant association noted between CK and muscle adverse events (p = 0.5637). The rs4363657 polymorphism of SLCO1B1 gene was significantly associated with muscle adverse events (p < 0.0001). The frequency of muscle adverse events was highest in CC genotype (100%); TC and TT (wild type) genotypes were 42.31% and 3.57%, respectively. Subjects with TC and CC genotypes were 26.24 and 357.96 times more likely to exhibit muscle adverse events compared to subjects with normal SLCO1B1 gene, respectively (p < 0.0001).
Conclusion
Statin-associated muscle adverse events were significantly higher in subjects on lovastatin compared to simvastatin. rs4363657 polymorphism of SLCO1B1 gene was a significant risk factor for statin-associated muscle adverse events in this study.
Keywords:
Dyslipidemia,
statin,
muscle adverse events,
SLCO1B1,
rs4363657,
Creatine Kinase,
Simvastatin,
Lovastatin
Conference:
International Conference on Drug Discovery and Translational Medicine 2018 (ICDDTM '18)
“Seizing Opportunities and Addressing Challenges of Precision Medicine”, Putrajaya, Malaysia, 3 Dec - 5 Feb, 2019.
Presentation Type:
Poster Presentation
Topic:
Metabolic diseases
Citation:
Meor Anuar Shuhaili
M,
Chew
B,
Samsudin
I,
Abdul Rahman
H,
Stanslas
J,
Hasan
S,
Ahmad
Z and
C. Thambiah
S
(2019). A Pilot Study on the Association between SLCO1B1 rs4363657 Polymorphism and Muscle Adverse Events in Adults with Newly Diagnosed Dyslipidaemia who were Prescribed a Statin: The Malaysian Primary Health Care Cohort.
Front. Pharmacol.
Conference Abstract:
International Conference on Drug Discovery and Translational Medicine 2018 (ICDDTM '18)
“Seizing Opportunities and Addressing Challenges of Precision Medicine”.
doi: 10.3389/conf.fphar.2018.63.00003
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Received:
11 Oct 2018;
Published Online:
17 Jan 2019.
*
Correspondence:
Dr. Subashini C. Thambiah, Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor Daruh Ehsan, Selangor, 43400, Malaysia, subashini@upm.edu.my