Event Abstract

Back to Event

A compact integrated system for neural signal acquisition and stimulation

Luca Pazzini1, Davide Polese1*, Marco Marrani1, Francesco Maita1, Nuria Tort2, Julia F. Weinert2, Mattia D'Andola2, Luca Maiolo2, Alessandro Pecora1, Guglielmo Fortunato1 and Maria V. Sanchez-Vives2
  • 1 Consiglio Nazionale delle Ricerche - Istituto per la Microelettronica e Microsistemi, Italy
  • 2 Institut d'Investigacions Biomèdiques August Pi i Sunyer, Spain

The mechanism by which the neural networks communicate and the understanding of these processes remains the fundamental issue of neuroscience. Long-term brain activity registration and stimulation is the main ally to analyze and interpret data coming from the brain. Several materials and microelectronics techniques have been pursued to obtain reliable and long lasting implantable devices from intracortical electrodes to soft epicortical arrays. Among them, ultra-flexible interfaces result particular appealing for their superior conformability and intimate contact with the brain tissue, especially for epicortical devices, thus achieving higher signals and reducing brain injuries. By other side, also external electronics is important properly to treat the signal, filtering the artifacts and minimizing the noise. In this paper, a novel compact integrated system for both brain stimulation and recording is presented. The device consisted in an ultra-flexible polyimide 32-channel microelectrodes array (8 um thick) connected to a miniaturized PCB able to amplify, filter and digitalize the neural signals. The size of this acquiring board is 60x45 mm and it provides an amplification of 200x with a sampling rate greater than 1 MSamples/s. The system has been successfully tested both in-vivo and in-vitro experiments on Wistar rat demonstrating that it could be a good candidate for a further miniaturization of the measurement equipment.

Acknowledgements

This work was partially supported by the EU Project CORTICONIC whose objective is related to the identification of computational principles of the cerebral cortex underlying network dynamic patterns.

References

[1] D-H. Kim et al., “Dissolvable Films of Silk Fibroin for Ultrathin, Conformal Bio-Integrated Electronics”, Nat. Mater. 2010 June ; 9(6): 511–517
[2] T. Stieglitz and J. U. Meyer, “Microtechnical interfaces to neurons,” Microsyst. Technol. Chem. Life Sci., pp. 131–162, 1997
[3] P. R. Kennedy, “The cone electrode: A long-term electrode that records from neurites grown onto its recording surface,” J. Neurosci. Methods, vol. 29, no. 3, pp. 181–193, Sept. 1989
[4] D. Khodagholy et al., “NeuroGrid: recording action potentials from the surface of the brain”, Nat. Neuroscience, 2014, doi:10.1038/nn.3905
[5] M.A. Nicolelis et al., Science 268 (1995).
[6] P.J. Rousche et al., IEEE Transactions on Biomedical Engineering 48, (2001).
[7] E. Margalit et al., Surv Ophthalmol 47 (2002).
[8] S. Xu, S.K. Talwar, E.S. Hawley, L. Li, J.K. Chapin, “A multi-channel telemetry system for brain microstimulation in freely roaming animals”, J Neurosci Methods 2004;133:57–63.
[9] C.-N. Chien, F.-S. Jaw, “Miniature telemetry system for the recording of action and field potentials”, Journal of Neuroscience Methods 147 (2005) 68–73
[10] E. Castagnola, L. Maiolo, et al. PEDOT-CNT-coated low-impedance, ultra-flexible, and brain-conformable micro-ECoG arrays”, IEEE Trans. on Neural Systems and Rehabilitation Engineering,

Keywords: Neural acquisition, Neural Stimulation, Integrated System, microelectrode array, Brain machine interface (BMI)

Conference: B·DEBATE | A Dialogue with the Cerebral Cortex: Cortical Function and Interfacing (Workshop), Barcelona, Spain, 29 Apr - 30 Apr, 2015.

Presentation Type: Poster Presentation

Topic: SESSION 4: Decoding Brain Activity and the Future of Brain Computer Interfaces

Citation: Pazzini L, Polese D, Marrani M, Maita F, Tort N, Weinert JF, D'Andola M, Maiolo L, Pecora A, Fortunato G and Sanchez-Vives MV (2015). A compact integrated system for neural signal acquisition and stimulation. Front. Syst. Neurosci. Conference Abstract: B·DEBATE | A Dialogue with the Cerebral Cortex: Cortical Function and Interfacing (Workshop). doi: 10.3389/conf.fnsys.2015.06.00011

Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters.

The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated.

Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed.

For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions.

Received: 24 Apr 2015; Published Online: 06 May 2015.

* Correspondence: Dr. Davide Polese, Consiglio Nazionale delle Ricerche - Istituto per la Microelettronica e Microsistemi, Rome, Italy, davidepolese@gmail.com