Analysis of motor activity and thermoregulation after juvenile capsaicin desensitization
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1
University of Szeged, Department of Neurology, Faculty of Medicine, Hungary
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2
University of Szeged, Department of Physiology, Faculty of Medicine, Hungary
Ablation of the TRPV1 receptors produces several sensory changes. Typically, animals show attenuated inflammatory pain and abnormal urinary bladder volume. It is well known that these receptors have significant role in the central nervous system as well. In the present study, we investigated the effects of juvenile capsaicin desensitization on the motor activity and body temperature in awake, freely moving rats. Methods: 21 days old male Wistar rats, after weaning, were desensitized by high dose of (180 mg/kg i.p.). Control animals received physiological saline. The body weight, the blepharosmasm and paw wiping reflex of the eye were determined repeatedly. At the age between 4 and 6 month animals were implanted with MiniMitter transmitters, and after one week recovery body temperature and motor activity were registered for 4 days in temperature controlled room (22 °C). Results: The body weight did not differ between the two groups. Capsaicin-treated animals showed complete and long-lasting abolishment of eye-wipe responses and blepharospasm, suggesting that desensitization prevented the painful effects of capsaicin eye drops. Both groups showed circadian rhythm of the body temperature and motor activity, and significant correlation was detected between the two parameters. However, disturbance in thermoregulation has been observed in desensitized rats since during the active period (at night) their body temperature was significantly higher compared to control animals, while at the light phase the opposite results were observed. As regards the locomotor activity a trend for the decreased activity was observed in their active phase. Our results suggest that juvenile capsaicin desensitization produced sustained alterations in these physiological parameters, and these changes are similar to alterations observed after adult capsaicin desensitization. This work was supported by the TÁMOP 4.2.2.-08/01-2008-0002 and a Hungarian Research Grant (OTKA, K60278).
Conference:
IBRO International Workshop 2010, Pécs, Hungary, 21 Jan - 23 Jan, 2010.
Presentation Type:
Poster Presentation
Topic:
Sensory and motor systems
Citation:
Tuboly
G,
Ádám
G,
Kékesi
G,
Benedek
G,
Horváth
G and
Joó
G
(2010). Analysis of motor activity and thermoregulation after juvenile capsaicin desensitization.
Front. Neurosci.
Conference Abstract:
IBRO International Workshop 2010.
doi: 10.3389/conf.fnins.2010.10.00057
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Received:
21 Apr 2010;
Published Online:
21 Apr 2010.
*
Correspondence:
Gábor Ádám, University of Szeged, Department of Physiology, Faculty of Medicine, Szeged, Hungary, adamgabesz@hotmail.com