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Mathematical Anxiety influences the cortical connectivity profiles in lower alpha band during working memory tasks

Seyma Bayrak1, Daniel S. Margulies1, Panagiotis D. Bamidis2 and Manousos A. Klados1*
  • 1 Max Planck Institute for Human Cognitive and Brain Sciences, Germany
  • 2 Aristotle University of Thessaloniki, Greece

Introduction Highly math-anxious (HMA) individuals are characterized by a strong tendency to avoid math, which ultimately undercuts their math competence and forecloses important career paths (Ashcraft, 2002). It is hypothesized that worries and intrusive thoughts associated with math anxiety (MA) reduce working memory resources needed for cognitively demanding math tasks (Chang & Beilock, 2016). However, mental processes that access the memory representations of mathematical knowledge has not been fully uncovered (Ashcraft, 2001). Previous studies indicate that the frontal cortex is dominantly involved in working memory (WM) and more specifically while updating the working memory representations (Smith & Jonides, 1997). Additionally, Klados et. al. 2015 show that higher event-related potential (ERP) measures of HMA subjects are predominantly located at frontocentral sites at cortex, while performing WM tasks. Here, we aim to explore the changes in cortical connectivity profile induced by MA during WM tasks. Methods EEG recordings were measured from 32 adults during performance of WM tasks with two levels of difficulty, 1-back (BT1) and 2-back (BT2) (Klados et al., 2015). According to the Abbreviated Math Anxiety Scale (AMAS), half of the participants were selected among the highly math anxious (HMA) students, whereas the other half had low math anxiety (LMA) (Hopko et al., 2003). ERPs were recorded via a Neurofax EEG-1200 system from 57 electrode sites according to a modified international 10/10 system using an Electrocap. Epoch length was 1200 ms including 200 ms prestimulus baseline. Signals were filtered offline between 0.5 and 45 Hz and submitted to an ICA procedure to identify ocular artifact components (Bell & Sejnowski, 1995). These artifact components were filtered with REGICA (Schlögl et al., 2007, Klados et al., 2009, 2011). Resulting waveforms were inspected visually and epochs containing visible artifacts in the first 500 ms post-stimulus were removed. To overcome the impact of varying electrical conductivity among head compartments on functional connectivity analyses (Nolte et. al., 200), the cortical activity was estimated from 28 EEG signals by adopting a cortical dipole model (He & Wu, 1999, Mattia et. al., 2009). Here, we referenced MNI152 template as an average head model. Scalp, cortex, outer- and inner-skull were extracted by implementing the Boundary Element Method (BEM) with 302 nodes (Uscedu, 2016). Finally, a column-norm normalization was used to prevent the linear inverse problem. This way, we obtained a transition kernel from 57 scalp signals to 302 cortical signals.    We constructed connectivity matrices based on 302 cortical signals by using Magnitude Squared Coherence (MSC) in upper alpha band (8-10 Hz) (Lithari et. al., 2012, Klados et. al., 2013). Then, we embed these connectivity networks to the “connectivity components” by employing a nonlinear dimensional reduction technique (Coifman & Lafon, 2016). The first component captures the highest variance, i.e. the similarity/dissimilarity of the connectivity patterns of source regions. We used 2-way ANOVA with factors MA (HMA & LMA) and task difficulty (BT1 & BT2) along the first connectivity component. The p-values were adapted by the FDR correction (Benjamini & Hochberg, 1995).   Results    Fig.1 demonstrates the mixed effect of group by task interaction on the connectivity profiles. There is a significant interaction between MA and task difficulty, that is prominent in dorsolateral prefrontal cortex (DLPFC), temporal lobe, left ventromedial PFC, right inferior-parietal lobule (IPL), somatosensory and right motor areas.   For each significant region (p(G x T)<0.05, Fig.1), the average connectivity map in HMA and LMA groups while performing BT1/BT2 tasks (Fig.2) were obtained. In order to explore the brain regions, whose connectivity pattern is mainly driven by MA or task difficulty, we used t-tests. The connectivity components of significant regions (Fig.1) obtained from HMA-BT1, LMA-BT1, HMA-BT2, LMA-BT2 maps (Fig.2) were pairwise compared (Fig.3). Fig.3 (A, B) illustrates that the significant effect of task difficulty on connectivity patterns widens itself towards IPL and somatosensory cortex, and also shifts from posterior to anterior parts of ventromedial PFC in LMA group. Fig.3 (C, D) illustrates that the significant effect of MA expands towards DLPFC, ventromedial PFC and temporal lobe with increasing task difficulty. Increasing task difficulty significantly strengthens connections to DLPFC regions, but lowers to the IPL and temporal cortex in right hemisphere in HMA individuals (Fig.2, A, C, Fig.3, A). This effect is similar in LMA individuals, except that their DLPFC connection strengths are reduced (Fig.2, B, C, Fig.3, B). HMA subjects have reduced connections to the right IPL, DLPFC, somatomotor cortex, but stronger connections to left medial temporal cortex, while performing BT1 task (Fig.2, A, B, Fig.3, C). However, HMA individuals tend to have significantly stronger connections to almost all temporal regions at BT2 task (Fig.2, C, D, Fig.3, D). Discussion MA level of individuals has a strong effect on the connectivity pattern of brain regions responsible for WM task performances. We demonstrated that, the connectivity patterns vary mostly in DLPFC,  IPL, temporal and somatosensory cortices across HMA and LMA groups. Specifically, HMA participants reveal stronger activations in right temporal cortex. Considering the low localization power of EEG, our findings might reflect the activity of hippocampus and amygdala, which is included in fear processing (Etkin & Wager 2007). Our results seem to agree with the study of Young et. al. (2010), where HMA individuals show hyperactive connectivity in right amygdala and anterior hippocampus. We also presented that LMA individuals retain effective connections to IPL, which reveals consistency with the literature (Lyons &  Beilock, 2012). We found that HMA participants reveal a reduced DLPFC activation during BT1 task, however, an increased DLPFC activation during BT2 task.

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Keywords: Math Anxiety, Diffusion Magnetic Resonance Imaging, connectivity, EEG, functional connectivity

Conference: SAN2016 Meeting, Corfu, Greece, 6 Oct - 9 Oct, 2016.

Presentation Type: Oral Presentation in SAN 2016 Conference

Topic: Oral Presentations

Citation: Bayrak S, Margulies DS, Bamidis PD and Klados MA (2016). Mathematical Anxiety influences the cortical connectivity profiles in lower alpha band during working memory tasks. Conference Abstract: SAN2016 Meeting. doi: 10.3389/conf.fnhum.2016.220.00001

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Received: 24 Jul 2016; Published Online: 30 Jul 2016.

* Correspondence: Dr. Manousos A Klados, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, 04103, Germany, mklados@gmail.com