ADVERSE RESPONSE TO VITAMIN B6 IN A 43 YEAR OLD WOMAN
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1
Carrick Institute, United States
Background:
A 43 year old woman presented with a history of episodes and symptoms suggestive of stroke or transient ischemic attack. The initial episode occurred after apparent overhydration. She experienced numbness on the right side of her tongue and face, as well as feeling as if her right ear was “curling” and her skin “sliding” off her skull. In the Emergency Department imaging and electrocardiogram were normal. Blood chemistry at that time revealed low potassium, sodium and magnesium. Over the next few months, prior to presentation, she was diagnosed with non-celiac gluten sensitivity, pre-diabetes and perimenopause.
Methods:
Blood chemistry was unremarkable. Given her symptoms and history she was started on an anti-inflammatory diet and supplement protocol. Because she experienced reactive hypoglycemic symptoms, she was placed on a multi-nutrient formula to support glucose regulation. At her initial dosage she was ingesting 66 mg of B6 per day. After a few weeks, she reported tingling in her extremities and right side of her face.
The multi-nutrient formula was switched to a B-complex. At that time she was now ingesting 55 mg of B6 per day. She reported no tingling in the few weeks after the switch.
Two months after using the protocol containing 55 mg per day of Vitamin B6, she began experiencing minor occurrences of the tingling. Four months after taking the protocol containing 55 mg per day of B6, she began to experience increased frequency of tingling. Also, at this time she began experience occasional urinary leakage with increased intrapelvic pressure, but also had difficulty emptying her bladder.
After 6 months of taking 55 mg per day of B6, plasma B6 levels were tested and found to be elevated (>100 mcg/L)
She avoided all supplemental sources of B6 for 30 days.
Results:
After 30 days of abstaining from B6 supplementation, plasma levels of B6 were retested and found to be normal (14 mcg/L). During the time she abstained from B6 her bladder symptoms disappeared, as did her periodic paresthesias.
We attempted to supplement with B6 again, but the tingling and paresthesias returned. As long as she ingested no B6 she did not experience any tingling or abnormal sensations.
Conclusion:
The author suggests further investigation into the possible role of supplemental Vitamin B6 in abnormal sensory symptoms and paresthesias.
Keywords:
Vitamin B6,
supplementation,
Paresthesia,
Adverse Reactions,
Pyridoxine
Conference:
International Symposium on Clinical Neuroscience 2018, Orlando, Florida, United States, 24 May - 26 May, 2018.
Presentation Type:
Poster
Topic:
Clinical Applications in health, disease, and injury to the nervous system
Citation:
Clark
DJ
(2018). ADVERSE RESPONSE TO VITAMIN B6 IN A 43 YEAR OLD WOMAN
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Front. Neurol.
Conference Abstract:
International Symposium on Clinical Neuroscience 2018.
doi: 10.3389/conf.fneur.2018.60.00011
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Received:
26 Mar 2018;
Published Online:
14 Dec 2018.
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Correspondence:
Dr. David J Clark, Carrick Institute, Cape Canaveral, United States, mail@doctordavidclark.com