Myelopathy/tropical spastic paraparesis associated to human T cell lymphotropic virus type 1. A case report
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1
Hospital General Juan Bruno Zayas, Inmunología, Cuba
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2
Hospital General Juan Bruno Zayas, Department of Immunology, Cuba
The human T-cell lymphotropic virus type 1 (HTLV-1) is an oncogenic retrovirus that is transmitted from mother to child, particularly through prolonged breastfeeding, by sexual partners through unprotected intercourse and from donors to recipients through transfusion and transplantation. Just as human immunodeficiency virus, it is a retrovirus with tropism for CD4+ T lymphocytes. The case of a 36 year-old female patient is presented with the diagnosis HTLV-1–associated myelopathy/tropical spastic paraparesis (HAM/TSP), who was admitted to the Internal Medicine Service at Juan Bruno Zayas Hospital, Santiago de Cuba, Cuba, in the month of January of the year 2014. The main immunologic and genetic alterations are described caused by the virus that generates a decrease in the immune response, as well as the clinical findings and laboratory results of interest. It was an interesting case to be the first case diagnosed in the service of a not very frequent pathology in our country.
Keywords:
HTLV-1,
mielopathy,
Tropical spastic paraparesis,
infection-associated autoimmunity,
CD4+ T lymphocytes
Conference:
IMMUNOCOLOMBIA2015 - 11th Congress of the Latin American Association of Immunology - 10o. Congreso de la Asociación Colombiana de Alergia, Asma e Inmunología, Medellin, Colombia, 13 Oct - 16 Oct, 2015.
Presentation Type:
Oral Presentation
Topic:
Infectious and parasitic diseases
Citation:
Rodríguez Peralta
N,
Fernández Arias
L,
Caballeros Artiles
RÁ and
Cabrales Rodríguez
A
(2015). Myelopathy/tropical spastic paraparesis associated to human T cell lymphotropic virus type 1. A case report.
Front. Immunol.
Conference Abstract:
IMMUNOCOLOMBIA2015 - 11th Congress of the Latin American Association of Immunology - 10o. Congreso de la Asociación Colombiana de Alergia, Asma e Inmunología.
doi: 10.3389/conf.fimmu.2015.05.00346
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Received:
30 May 2015;
Published Online:
15 Sep 2015.
*
Correspondence:
Dr. Noelsy Rodríguez Peralta, Hospital General Juan Bruno Zayas, Inmunología, Santiago de Cuba, Santiago de Cuba, Cuba, orlandosb@infomed.sld.cu