Clinical and molecular characterization of tuberculosis associated spinal lesions
Citlaltepetl
Salinas Lara1*,
Alejandro
Miguel Zambrano1,
Vania Iris
Bermúdez Mendoza1,
Ada María
Díaz Trejo1,
Adriana Isabel
Jaimes Nateras1,
Carlos
Sánchez Garibay1,
Elizabeth
Pérez Hernández2,
José
Arellano Galindo3,
María Elena
Hernández Campos4,
Adriana
Atencio Chan5,
Eulalio
Elizalde Martínez6,
Verónica
Ángeles Morales7 and
Martha Lilia
Tena Suck1
-
1
Instituto Nacional de Neurología y Neurocirugía, Departamento de Neuropatología, Mexico
-
2
UMAE “Dr. Victorio de la Fuente Narváez”, IMSS., Dirección de Educación e Investigación en Salud, Mexico
-
3
Hospital Infantil de México “Federico Gómez”, SSA., Departamento de Virología, Mexico
-
4
Escuela Superior de Medicina, Instituto Politécnico Nacional, Sección de Estudios de Posgrado e Investigación, Mexico
-
5
UMAE “Dr. Victorio de la Fuente Narváez”, IMSS., Servicio de Anatomía Patológica, Mexico
-
6
UMAE “Dr. Victorio de la Fuente Narváez”, IMSS., Servicio de Columna, Mexico
-
7
Instituto Nacional de Neurología y Neurocirugía, Departamento de Neuroinfectología, Mexico
Spinal tuberculosis (TB) is a chronic, infectious, granulomatous disease that affects the spine. It accounts for 50 percent of osteoarticular TB, and 1 to 3 percent of all TB cases; the disease is characterized by destruction of vertebral bodies and intervertebral discs which can cause life threatening complications. The current investigation was conducted as a case study in a tertiary care level whose objective was to characterize clinically and at a molecular level the spinal lesions related to Mycobacterium tuberculosis. Seventeen patient’s biopsies underwent study, clinical data was taken, TB presence was evaluated by PCR; histological patterns and molecular cytokine profile expression were assessed. We found no major difference in clinical data compared to other case studies; histopathology was typically that of any granulomatous lesion caused by TB; we also found the presence of pro-osteoclastogenic cytokines that contribute to inflammatory damage (IL-17, IL-23, IL-1β, TGF-β, however, there was a marked absence of key cytokines needed for osteoclastogeneis regulation (TNF-α and RANKL).
Keywords:
osteoimmunology,
inflammatory bone loss,
Interleukin-17,
Interleukin-23,
spinal tuberculosis
Conference:
IMMUNOCOLOMBIA2015 - 11th Congress of the Latin American Association of Immunology - 10o. Congreso de la Asociación Colombiana de Alergia, Asma e Inmunología, Medellin, Colombia, 13 Oct - 16 Oct, 2015.
Presentation Type:
Poster Presentation
Topic:
Infectious and parasitic diseases
Citation:
Salinas Lara
C,
Miguel Zambrano
A,
Bermúdez Mendoza
V,
Díaz Trejo
A,
Jaimes Nateras
A,
Sánchez Garibay
C,
Pérez Hernández
E,
Arellano Galindo
J,
Hernández Campos
M,
Atencio Chan
A,
Elizalde Martínez
E,
Ángeles Morales
V and
Tena Suck
M
(2015). Clinical and molecular characterization of tuberculosis associated spinal lesions.
Front. Immunol.
Conference Abstract:
IMMUNOCOLOMBIA2015 - 11th Congress of the Latin American Association of Immunology - 10o. Congreso de la Asociación Colombiana de Alergia, Asma e Inmunología.
doi: 10.3389/conf.fimmu.2015.05.00153
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Received:
31 May 2015;
Published Online:
14 Sep 2015.
*
Correspondence:
MD, PhD. Citlaltepetl Salinas Lara, Instituto Nacional de Neurología y Neurocirugía, Departamento de Neuropatología, Distrito Federal, 14269, Mexico, cisala69@hotmail.com