Effect of hexoprenaline sulphate on the immunoglobulin production in the presence of thyroxine and hydrocortisone in vitro
-
1
Acad. E.A. Wagner Perm State Medical Academy, immunology, Russia
-
2
Institute of Ecology and Genetics of Microorganisms of UB RASciences, Russia
Adrenergic compounds, thyroid hormones and glucocorticoids play an important role in the neuroendocrine regulation of the immune system in health and disease. It is known that administration of thyroid hormones and glucocorticoids lead to the increase in expression of beta-adrenoceptors and/or intracellular signal transduction in target cells of various organs. Functional implications of such interaction at the level of the immune system are not fully understood yet. The aim of this work was to investigate the effect of beta-adrenoceptor agonist hexoprenaline sulphate on the production of immunoglobulins in the presence of thyroxine and hydrocortisone in vitro in cultures of human mononuclear cells of practically healthy volunteers. It was established that addition of thyroxine (10-8 M) in cultures with pokeweed mitogen (PWM) led to increase in the IgG production. Hexoprenaline sulfate (10-6 M) abolishes this effect in cultures with thyroxine, but has no affect on the IgG production in cultures without thyroxine. Hydrocortisone (10-6 M) has no influence on production of IgG alone and along with hexoprenaline sulfate (10-6 M). All compounds have no effect on production of IgM. This study was supported by the programs of the Presidium of the Russian Academy of Sciences “Molecular and Cell Biology” and “Fundamental Science for Medicine”.
Keywords:
immunoglobulin production,
Thyroxine,
Hydrocortisone,
beta-adrenoceptor agonist,
Neuroendocrine regulation
Conference:
15th International Congress of Immunology (ICI), Milan, Italy, 22 Aug - 27 Aug, 2013.
Presentation Type:
Abstract
Topic:
Immune-mediated disease pathogenesis
Citation:
Godovalov
AP,
Shilov
DJ and
Shilov
JI
(2013). Effect of hexoprenaline sulphate on the immunoglobulin production in the presence of thyroxine and hydrocortisone in vitro.
Front. Immunol.
Conference Abstract:
15th International Congress of Immunology (ICI).
doi: 10.3389/conf.fimmu.2013.02.00516
Copyright:
The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers.
They are made available through the Frontiers publishing platform as a service to conference organizers and presenters.
The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated.
Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed.
For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions.
Received:
11 Jun 2013;
Published Online:
22 Aug 2013.
*
Correspondence:
Mr. Anatoliy P Godovalov, Acad. E.A. Wagner Perm State Medical Academy, immunology, Perm, Russia, AGodovalov@gmail.com