The study of the prevention dressing of keloid
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1
Chung Shan Medical University, School of Medical Laboratory and Biotechnology, Taiwan
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2
I-Shou University, Department of Biomedical Engineering, Taiwan
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3
China Medical University, Department of Biomedical Imaging and Radiological Science, Taiwan
A keloid is a firm scar which is the result of an overgrowth of dense fibrous tissue at the site of a healed skin injury. Vitamin C acts as an essential cofactor for the synthesis of collagen. Caffeine is thought to inhibit the absorption of vitamin C. The goal of the study was to use silicone gel with caffeine to prevent the formation of keloid. The preliminary results showed that the release of caffeine was not significantly different between different silicone gel groups(Figure 1). MTT results showed that 10mM caffeine could retard the proliferation of L929 fibroblasts. RT-PCR results revealed that caffeine could decrease the gene expression of collagen I and ACTC1(Figure 2).
References:
[1] Sclafani AP et al. (1996)″Prevention of earlobe keloid recurrence with postoperative corticosteroid injections versus radiation therapy: a randomized, prospective study and review of the literature. ″ Dermatol Surg,22(6):569-74.
[2] Jeffrey C. Geesin et al. (1988)″Ascorbic Acid Specifically Increases Type I and Type III procollagen messenger RNA levels in human skin fibroblasts. ″Journal of Investigative Dermatology, Apr88, Vol. 90 Issue 4, p420-424.
[3] Torregrossa MM et al. (2011)“Aberrant learning and memory in addiction”Neurobiol Learn Mem 96(4):609-23.
[4] Eunsil Hahm et al. (2007)″The molecular mechanisms of vitamin on cell cycle regulation in B16F10 murine melanoma″Journal of Cellular BiochemistryVolume 102, Issue 4, pages 1002–1010.
[5] A.W. Chua, D. Ma, S.U. Gan, Z. Fu, H.C. Han, C. Song, et al. (2010)The role of R-Spondin2 in keratinocyte proliferation and epidermal thickening in keloid scarringJ Invest Dermatol
Conference:
10th World Biomaterials Congress, Montréal, Canada, 17 May - 22 May, 2016.
Presentation Type:
Poster
Topic:
Regenerative medicine: biomaterials for control of tissue induction
Citation:
Lee
M,
Kuo
S,
Yao
C,
Chen
F and
Chang
S
(2016). The study of the prevention dressing of keloid.
Front. Bioeng. Biotechnol.
Conference Abstract:
10th World Biomaterials Congress.
doi: 10.3389/conf.FBIOE.2016.01.00476
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Received:
27 Mar 2016;
Published Online:
30 Mar 2016.