Probiotic supplementation during pregnancy and early childhood in the prevention of atopic dermatitis: A literature review
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1
Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Malaysia
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2
Taylor's University, Malaysia
Background
Atopic dermatitis (AD) is an increasingly prevalent chronic skin disorder that results in progression to atopic march. The hygiene theory has been postulated to have caused the rise in the incidence of atopic diseases among urban living. Early alteration of gut microbiota has been postulated to have immuno-regulatory effects, causing reduction in the incidence of atopic dermatitis. A literature search was therefore performed on randomized controlled trials that evaluate the effects of probiotic supplementation during pregnancy and early infancy in the prevention of atopic dermatitis.
Methods
To assess the effects of probiotic supplementation during pregnancy and early infancy in the prevention of AD in children, PubMed database was searched for randomized controlled trials that were published in English language.
Results
Based on the search string, a total of 236 articles were identified. Two studies were further identified after listing the references of existing meta-analysis or systematic review. After going through the inclusion and exclusion criteria, a total of 14 studies comprising of 4712 subjects were included in the final analysis. Lactobacillus spp were used in 5 studies, Bifidobacterium spp. in 2 studies and a combination of probiotic strains in 8 studies. Probiotics were mainly initiated for 4-6 weeks before delivery and continued postnatally for an average of 6 months. Eight out of the 14 articles demonstrated a significant reduction in the incidence of atopic dermatitis in the probiotic arm. A combination of probiotic strains appeared to be superior when compared to a single strain probiotic in the prevention of atopic dermatitis.
Conclusion
Probiotics appeared to have a protective role in AD prevention if initiated during pregnancy and early infancy. Further analysis of the current data is, however, required.
Keywords:
atopic dermatitis,
probiotic,
pregnant,
Lactobacillus,
Bifidobacterium
Conference:
International Conference on Drug Discovery and Translational Medicine 2018 (ICDDTM '18)
“Seizing Opportunities and Addressing Challenges of Precision Medicine”, Putrajaya, Malaysia, 3 Dec - 5 Feb, 2019.
Presentation Type:
Oral Presentation
Topic:
Inflammatory diseases
Citation:
How
K,
Lai
Z and
Thong
P
(2019). Probiotic supplementation during pregnancy and early childhood in the prevention of atopic dermatitis: A literature review.
Front. Pharmacol.
Conference Abstract:
International Conference on Drug Discovery and Translational Medicine 2018 (ICDDTM '18)
“Seizing Opportunities and Addressing Challenges of Precision Medicine”.
doi: 10.3389/conf.fphar.2018.63.00085
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Received:
30 Sep 2018;
Published Online:
17 Jan 2019.
*
Correspondence:
Dr. Kang Nien How, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Malaysia, hkangnien@upm.edu.my