A novel biomaterial with controllable biodegradation for bone regeneration
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1
Institute of Biomedicine and Biotechnology, Center for Human Tissue and Organs Degeneration, China
The degradation rate of an ideal scaffold material should be comparable to the tissue growth rate, as the implant needs to maintain mechanical properties initially to bear loads, but over time the load bearing should transfer onto the newly forming tissue. Thus, the degradation properties and degradation rate of the scaffolds material must be under control by precisely individually designing, to satisfy the tissue growth rate. The aim of this research is to investigate the novel polymeric biomaterials with controllable degradation as potential scaffold for bone regeneration. First of all, a series of novel piperazine-based polyurethane ureas (P-PUUs) with the different and controllable content of piperazine (PP) have been designed and prepared with PDLLA diol, HDI and PP as the chain extender. And then the controlled degradable properties of P-PUUs were investigated by in vitro degradation with detecting the changes of the pH value of incubation media, weight loss, water absorption rate and the molecular weight during 12 weeks. Moreover, the mechanical properties of P-PUUs during degradation were calculated by tensile measurements. The results revealed that regulating the ratio of PDLLA diol: HDI: PP can precisely control the number of PP units (Num (PP)) in P-PUUs, and affected the degradation stability, degradation rate of P-PUUs. The linear correlation between the degradation rate of P-PUUs and Num (PP) would suggest the P-PUUs with the controlled degradability. Meanwhile, the change of Mechanical properties of P-PUUs relied heavily on their stable degradation and the P-PUUs with higher Num (PP) had impressive mechanical properties during the degradation process to facilitate to maintain mechanical properties in bone repairing.
The National Natural Science Foundation of China (NO. 31200723); The Shenzhen Peacock Program (NO. 110811003586331); The Development Project of Strategic Emerging Industries of Shenzhen (NO. JCYJ20140417113430596)
Keywords:
Tissue Engineering,
Biodegradable material,
Polymeric material
Conference:
10th World Biomaterials Congress, Montréal, Canada, 17 May - 22 May, 2016.
Presentation Type:
Poster
Topic:
Biodegradable polymers
Citation:
Ruan
C and
Pan
H
(2016). A novel biomaterial with controllable biodegradation for bone regeneration.
Front. Bioeng. Biotechnol.
Conference Abstract:
10th World Biomaterials Congress.
doi: 10.3389/conf.FBIOE.2016.01.01691
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Received:
27 Mar 2016;
Published Online:
30 Mar 2016.