In vitro evaluation of biodegradable magnesium alloys containing micro-alloying additions of strontium, with and without zinc
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1
Monash University, Materials Science and Engineering, Australia
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2
The Australian National University, Research School of Engineering, Australia
Abstract: The in vitro degradation of magnesium (Mg) alloys containing low levels of strontium (Sr, 0.05, 0.1 and 0.2 wt.%) with and without additions of zinc (Zn, 0.5 and 1.0 wt.%), was studied for potential use in orthopaedic fracture treatments. Sr-containing Mg-alloys were selected as a promising strategy to utilise the biological role of Sr through alloying, to induce accelerated bone tissue growth. The influence of controlled alloying upon degradation rate was studied via electrochemical measurements and immersion tests in minimum essential medium (MEM). Immersion testing revealed a comparable degradation rate of the alloys tested herein, indicating no detrimental effect of Sr on degradation. Cytotoxicity experiments on primary mouse osteoblasts indicated good biocompatibility and enhanced proliferation of osteoblasts for all the tested Mg alloys. Potentiodynamic polarisation testing further confirmed that low-level additions of Sr imparted a minor influence on cathodic kinetics, with a slight inhibition of anodic kinetics. In contrast, the addition of Zn as a ternary element moderated both anodic and cathodic kinetics of Mg-Sr alloys.
Xiaojian Xia
Keywords:
Tissue Engineering,
in vitro,
material design,
Biodegradable metal
Conference:
10th World Biomaterials Congress, Montréal, Canada, 17 May - 22 May, 2016.
Presentation Type:
Poster
Topic:
Metallic biomaterials and alloys
Citation:
Wang
J,
Mukherjee
S,
Nisbet
D,
Birbilis
N and
Chen
X
(2016). In vitro evaluation of biodegradable magnesium alloys containing micro-alloying additions of strontium, with and without zinc.
Front. Bioeng. Biotechnol.
Conference Abstract:
10th World Biomaterials Congress.
doi: 10.3389/conf.FBIOE.2016.01.01355
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Received:
27 Mar 2016;
Published Online:
30 Mar 2016.
*
Correspondence:
Dr. Junlan Wang, Monash University, Materials Science and Engineering, Melbourne, Australia, junlan.wang@monash.edu
Dr. Shayanti Mukherjee, The Australian National University, Research School of Engineering, Canberra, Australia, shayanti.mukherjee@gmail.com
Dr. David Nisbet, The Australian National University, Research School of Engineering, Canberra, Australia, david.nisbet@anu.edu.au
Dr. Nick Birbilis, Monash University, Materials Science and Engineering, Melbourne, Australia, nick.birbilis@monash.edu
Dr. Xiaobo Chen, Monash University, Materials Science and Engineering, Melbourne, Australia, xiaobo.chen@monash.edu