Simultaneous tumor-photothermal therapy and bone-tissue regeneration by a bifunctional 3D-pringting bioceramic scaffold
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1
Shanghai Institute of Ceramics, Chinese Academy of Sciences, State Key Laboratory of High Performance Ceramics and Superfine Microstructure, China
Malignant bone tumor is one of the major bone diseases. The treatment of such a bone disease typically requires the removal of bone tumor and regeneration of tumor-initiated bone defects simultaneously. To address this issue, it is required that implanted biomaterials should combine the bifunctions of both therapy and regeneration. In this work, a bifunctional graphene oxide (GO)-modified β-tricalcium phosphate (GO-TCP) composite scaffold combining high photothermal effect with significantly improved bone-forming ability was prepared by 3D-printing and surface-modification strategies. The prepared GO-TCP scaffolds exhibited excellent photothermal effects under the irradiation of 808nm near infrared laser (NIR) even at an ultra-low power density of 0.36W/cm2, while no photothermal effects were observed for pure β-TCP scaffolds. The photothermal temperature of GO-TCP scaffolds could be effectively modulated in the range of 40~90°C by controlling the used GO concentrations, surface-modification times and power densities of NIR. The distinct photothermal effect of GO-TCP scaffolds induced more than 90% of cell death for osteosarcoma cells (MG-63) in vitro, and further effectively inhibited tumor growth in mouse. Meanwhile, the prepared GO-TCP scaffolds possessed the improved capability to stimulate the osteogenic differentiation of rabbit bone mesenchymal stem cells (rBMSCs) by upregulating bone-related gene expression, and significantly promoted new bone formation in the bone defects of rabbits as compared to pure β-TCP scaffolds. These results successfully demonstrated that the prepared GO-TCP scaffolds have bifunctional properties of photothermal therapy and bone regeneration, which is believed to pave the way to design and fabricate novel implanting biomaterials in combination of therapy and regeneration functions.
the National High Technology Research and Development Program of China (863 Program, SS2015AA020302)
Keywords:
Bone Regeneration,
Tissue Engineering,
3D scaffold
Conference:
10th World Biomaterials Congress, Montréal, Canada, 17 May - 22 May, 2016.
Presentation Type:
New Frontier Oral
Topic:
Ceramics
Citation:
Wu
C and
Chang
J
(2016). Simultaneous tumor-photothermal therapy and bone-tissue regeneration by a bifunctional 3D-pringting bioceramic scaffold.
Front. Bioeng. Biotechnol.
Conference Abstract:
10th World Biomaterials Congress.
doi: 10.3389/conf.FBIOE.2016.01.01258
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Received:
27 Mar 2016;
Published Online:
30 Mar 2016.