Original Research

Published on 09 May 2024

Improving prediction of tacrolimus concentration using a combination of population pharmacokinetic modeling and machine learning in chinese renal transplant recipients

in Drug Metabolism and Transport

Yu-Ping Wang
Xiao-Ling Lu
Kun Shao
Hao-Qiang Shi
Pei-Jun Zhou
Bing Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1389271

Review

Published on 07 May 2024

Advancements and challenges in pharmacokinetic and pharmacodynamic research on the traditional Chinese medicine saponins: a comprehensive review

in Drug Metabolism and Transport

Yuhan Ma
Yongxia Zhao
Mingxia Luo
Qin Jiang
Sha Liu
Qi Jia
Zhixun Bai
Faming Wu
Jian Xie

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1393409

148 views

Original Research

Accepted on 06 May 2024

Simultaneous determination of multiple components in rat plasma by UPLC-MS/MS for pharmacokinetic studies after oral administration of Pogostemon cablin extract

in Drug Metabolism and Transport

Yameng Zhu
Zhenguo Lv
Guangzhe Yao
Minglei Ge
Xiunan Cao
Yanxu Chang
Huizi Ouyang
Jun He

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1293464

Original Research

Accepted on 06 May 2024

Amino acid metabolomics and machine learning for assessment of post-hepatectomy liver regeneration

in Drug Metabolism and Transport

Yuqing Yan
Qianping Chen
Xiaoming Dai
Zhiqiang Xiang
Zhangtao Long
Yachen Wu
Hui Jiang
Jianjun Zou
Mu Wang
Zhu Zhu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1345099

Original Research

Accepted on 06 May 2024

Pharmacokinetic Assessment of Tacrolimus in combination with Deoxyschizandrin in rats

in Drug Metabolism and Transport

Jianguo Sun
Zhipeng Wang
Na Liu
Zhijun Liu
Lili Cui
Tao Xia
Wansheng Chen
Shouhong Gao
Zhijun Wu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1344369

Original Research

Accepted on 02 May 2024

Modulation of the photobehavior of gefitinib and its phenolic metabolites by human transport proteins

in Drug Metabolism and Transport

Lorena Tamarit
Meryem El Ouardi
Emilio Lence
Inmaculada Andreu
Concepción González-Bello
Miguel Angel Miranda
Ignacio Vaya

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1387057

Original Research

Published on 02 May 2024

Population pharmacokinetics of intravenous daptomycin in critically ill patients: implications for selection of dosage regimens

in Drug Metabolism and Transport

Jianhua Wu
Xiangyi Zheng
Liu Zhang
Jiajun Wang
Yifei Lv
Yujie Xi
Dongfang Wu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1378872

182 views

Original Research

Published on 02 May 2024

Physiologically based pharmacokinetic modeling to predict the pharmacokinetics of codeine in different CYP2D6 phenotypes

in Drug Metabolism and Transport

Yujie Yang
Xiqian Zhang
Yirong Wang
Heng Xi
Min Xu
Liang Zheng

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1342515

195 views

Original Research

Published on 29 Apr 2024

In vitro and in vivo metabolism of psilocybin’s active metabolite psilocin

in Drug Metabolism and Transport

Jan Thomann
Karolina E. Kolaczynska
Oliver V. Stoeckmann
Deborah Rudin
Patrick Vizeli
Marius C. Hoener
Christopher R. Pryce
Franz X. Vollenweider
Matthias E. Liechti
Urs Duthaler

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1391689

622 views

Original Research

Published on 29 Apr 2024

The first selective VAP-1 inhibitor in China, TT-01025-CL: safety, tolerability, pharmacokinetics, and pharmacodynamics of single- and multiple-ascending doses

in Drug Metabolism and Transport

Yuanxun Yang
Lei Yu
Zejuan Sheng
Hui Lin
Zuyi Weng
Wei Song
Bei Cao
Yu Zhao
Yingsheng Gao
Shumao Ni

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1327008

193 views

Original Research

Published on 29 Apr 2024

The impacts of natural product miltirone and the CYP2D6 pharmacogenetic phenotype on fluoxetine metabolism

in Drug Metabolism and Transport

Xiaodan Zhang
Qingqing Li
Xinwu Ye
Qing Chen
Chen Chen
Guoxin Hu
Likang Zhang
Lianguo Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1373048

196 views

Clinical Trial

Accepted on 22 Apr 2024

A single-dose, randomized, open-label, four-period, crossover equivalence trial comparing the clinical similarity of the proposed biosimilar rupatadine fumarate to reference Wystamm ® in healthy Chinese subjects

in Drug Metabolism and Transport

Sisi Lin
Yutao Lou
Rui Hao
Yiming Shao
Jin Yu
Lu Fang
Mei-hua Bao
Wu Yi
Yiwen Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1328142

Original Research

Published on 19 Apr 2024

Investigation of the hypoglycemic mechanism of the ShenQi compound formula through metabonomics and 16S rRNA sequencing

in Drug Metabolism and Transport

Juan Gao
Xiujuan Zhou
Hong Gao
Guiping Xu
Chunguang Xie
Hongyan Xie

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1349244

335 views

Original Research

Accepted on 18 Apr 2024

Evaluating the cardiovascular toxicity of polystyrene microplastics based on non-targeted metabolomics analysis

in Drug Metabolism and Transport

Liting Zhou
Zikai Song
Haidi Wu
Xiaoqi Fang
Xuemin Feng

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1336369

Original Research

Accepted on 16 Apr 2024

The influence of drug-induced metabolic enzyme activity inhibition and CYP3A4 gene polymorphism on aumolertinib metabolism

in Drug Metabolism and Transport

Feng Ye
Jinhuan Ni
Xinyue Li
Jing Wang
Jianchao Luo
Shiyu Wang
Xiaoyu Xu
Yunshan Zhong
Jianchang Qian
Zhongxiang Xiao

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1392849

Original Research

Published on 09 Apr 2024

Iodine-induced synthetic method and pharmacokinetic study of cis- and trans-crocetin

in Drug Metabolism and Transport

Boshen Li
Yuxuan Zhang
Zhiqiang Yang
Xiaolin Li
Jun Yang
Kai Luo
Renjie Wang
Chengrong Xiao
Maoxing Li
Yue Gao

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1364286

298 views

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Articles

Improving prediction of tacrolimus concentration using a combination of population pharmacokinetic modeling and machine learning in chinese renal transplant recipients

Advancements and challenges in pharmacokinetic and pharmacodynamic research on the traditional Chinese medicine saponins: a comprehensive review

Simultaneous determination of multiple components in rat plasma by UPLC-MS/MS for pharmacokinetic studies after oral administration of Pogostemon cablin extract

Amino acid metabolomics and machine learning for assessment of post-hepatectomy liver regeneration

Pharmacokinetic Assessment of Tacrolimus in combination with Deoxyschizandrin in rats

Modulation of the photobehavior of gefitinib and its phenolic metabolites by human transport proteins

Population pharmacokinetics of intravenous daptomycin in critically ill patients: implications for selection of dosage regimens

Physiologically based pharmacokinetic modeling to predict the pharmacokinetics of codeine in different CYP2D6 phenotypes

In vitro and in vivo metabolism of psilocybin’s active metabolite psilocin

The first selective VAP-1 inhibitor in China, TT-01025-CL: safety, tolerability, pharmacokinetics, and pharmacodynamics of single- and multiple-ascending doses

The impacts of natural product miltirone and the CYP2D6 pharmacogenetic phenotype on fluoxetine metabolism

A single-dose, randomized, open-label, four-period, crossover equivalence trial comparing the clinical similarity of the proposed biosimilar rupatadine fumarate to reference Wystamm ® in healthy Chinese subjects

Investigation of the hypoglycemic mechanism of the ShenQi compound formula through metabonomics and 16S rRNA sequencing

Evaluating the cardiovascular toxicity of polystyrene microplastics based on non-targeted metabolomics analysis

The influence of drug-induced metabolic enzyme activity inhibition and CYP3A4 gene polymorphism on aumolertinib metabolism

Iodine-induced synthetic method and pharmacokinetic study of cis- and trans-crocetin