AUTHOR=Külper-Schiek Wiebe , Piechotta Vanessa , Pilic Antonia , Batke Madeleine , Dreveton Léa-Sophie , Geurts Brogan , Koch Judith , Köppe Stefan , Treskova Marina , Vygen-Bonnet Sabine , Waize Maria , Wichmann Ole , Harder Thomas 

TITLE=Facing the Omicron variant—how well do vaccines protect against mild and severe COVID-19? Third interim analysis of a living systematic review

JOURNAL=Frontiers in Immunology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.940562

DOI=10.3389/fimmu.2022.940562

ISSN=1664-3224

ABSTRACT=Background: 
The SARS-CoV-2 Omicron variant is currently the dominant variant globally. This 3rd interim analysis of a living systematic review summarizes evidence on COVID-19 vaccine effectiveness (VE) and duration of protection against Omicron.
Methods: 
We systematically searched the COVID-19 literature for controlled studies evaluating the effectiveness of COVID-19 vaccines approved in the European Union up to 14/01/2022, complemented by hand-searches of websites and metasearch engines up to 11/02/2022. We considered the following comparisons: full primary immunization vs. no vaccination; booster immunization vs. no vaccination; booster vs. primary immunization. VE against any confirmed SARS-CoV-2 infection, symptomatic, and severe COVID-19 (i.e. COVID-19-related hospitalization, ICU-admission, or death) was indicated providing estimate ranges. Meta-analysis was not performed due to high study heterogeneity. Risk of bias was assessed with ROBINS-I, certainty of evidence evaluated using GRADE. 
Results: 
We identified 26 studies, including 430 to 2.2 million participants, that evaluated VE-estimates against infections with the SARS-CoV-2 Omicron variant. 
VE against any confirmed SARS-CoV-2 infection ranged between 0-62% after full primary immunization, and between 34-66% after a booster dose, if compared to no vaccination. VE-range for booster vs. primary immunization was 34-54.6%. 
Comparing full primary immunization to no vaccination VE against symptomatic respectively severe COVID-19, ranged between 6-76% respectively 3-84%, and between 19-73.9% respectively 12-100% after booster immunization. When comparing booster vs. primary immunization VE against symptomatic COVID-19 ranged between 56-69% and was 100% (95% CI 71.4-100) against severe COVID-19 based on data from only one study.
VE was characterized by a moderate to strong decline within three to six months for SARS-CoV-2 infections and symptomatic COVID-19. Against severe COVID-19 protection remained robust at least for up to six months. Waning immunity was more profound after primary than booster immunization. 
Risk of bias was moderate to critical across studies and outcomes. GRADE-certainty was very low for all outcomes.
Author’s conclusions: 
Under the Omicron variant, effectiveness of EU-licensed COVID-19 vaccines in preventing any SARS-CoV-2 infection or mild disease is low and only short-lasting after primary immunization, but can be improved by booster vaccination. VE against severe COVID-19 remains high and is long-lasting, especially after receiving the booster vaccination.