AUTHOR=Oldenburg Reid , Mayau Veronique , Prandi Jacques , Arbues Ainhoa , Astarie-Dequeker Catherine , Guilhot Christophe , Werts Catherine , Winter Nathalie , Demangel Caroline TITLE=Mycobacterial Phenolic Glycolipids Selectively Disable TRIF-Dependent TLR4 Signaling in Macrophages JOURNAL=Frontiers in Immunology VOLUME=9 YEAR=2018 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2018.00002 DOI=10.3389/fimmu.2018.00002 ISSN=1664-3224 ABSTRACT=
Phenolic glycolipids (PGLs) are cell wall components of a subset of pathogenic mycobacteria, with immunomodulatory properties. Here, we show that in addition, PGLs exert antibactericidal activity by limiting the production of nitric oxide synthase (iNOS) in mycobacteria-infected macrophages. PGL-mediated downregulation of iNOS was complement receptor 3-dependent and comparably induced by bacterial and purified PGLs. Using