AUTHOR=Michielsen Laura A. , Budding Kevin , Drop Daniël , van de Graaf Ed A. , Kardol-Hoefnagel Tineke , Verhaar Marianne C. , van Zuilen Arjan D. , Otten Henny G. TITLE=Reduced Expression of Membrane Complement Regulatory Protein CD59 on Leukocytes following Lung Transplantation JOURNAL=Frontiers in Immunology VOLUME=8 YEAR=2018 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2017.02008 DOI=10.3389/fimmu.2017.02008 ISSN=1664-3224 ABSTRACT=
Cellular protection against undesired effects of complement activation is provided by expression of membrane-bound complement regulatory proteins including CD59. This protein prevents membrane attack complex formation and is considered to be involved in graft accommodation. Also, CD59 downregulates CD4+ and CD8+ T-cell activation and proliferation. It is unknown whether CD59 expression is affected by transplantation. The aim of this study was to evaluate the quantitative CD59 antigen expression on distinct leukocyte subsets following lung transplantation (