Anti-inflammatory effect of celery squeezed juice on carrageenan induced rat paw edema
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1
Universitas Wahid Hasyim, Indonesia
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2
Diponegoro University, Indonesia
Background
Celery (Apium graveolens L.) contains several active compounds with some anti-inflammatory activities. The squeezed juice of celery is commonly used in the community to treat various diseases including inflammation. The aim of this study is to determine the anti-inflammatory effect of celery squeeze juice on acute inflammation.
Methods
The study design was two-groups pre- and post-test design. Samples were 16 male Wistar rats, age 12 weeks. Rats were randomly allocated into 2 groups: celery group (n=8) received 54 mg squeezed juice of celery per oral; control groups (n=8) received NaCl 0.9% per oral. One hour after celery or NaCl administration, the left paws were injected with carrageenan 1 % dissolved in 0.05 mL NaCl 0.9% intraplantar. Paw volumes were determined by plethysmography at 0 hour (before) until 4 hours with 1 hour interval. Repeated measure ANOVA and unpaired t-test were used for data analysis.
Results
The average paw volume at 0, 1, 2, 3 and 4 hours in celery group were 0.068±0.0085, 0.099±0.0136, 0.078±0.0131, 0.074±0.0115 and 0.073±0.0085 mL respectively (p<0.001); in control group were 0.078±0.0183, 0.100±0.0104, 0.089±0.0125, 0.087±0.0116 and 0.081±0.0099 mL (p<0.001). The differences of paw volume between celery group and control group at 0, 1 and 2 hours were not significantly different (p=0.1, p=0.8 and 0.2 respectively) but at 3 and 4 hours was significantly different (p=0.04 and 0.04 respectively)
Conclusion
Squeezed juice of celery has potency to inhibit acute inflammation
Keywords:
celery,
Apium graceolens,
Carrageenan,
rat,
Inflammation,
oedema (edema)
Conference:
International Conference on Drug Discovery and Translational Medicine 2018 (ICDDTM '18)
“Seizing Opportunities and Addressing Challenges of Precision Medicine”, Putrajaya, Malaysia, 3 Dec - 5 Feb, 2019.
Presentation Type:
Oral Presentation
Topic:
Inflammatory diseases
Citation:
Hudaya
S and
Hardian
H
(2019). Anti-inflammatory effect of celery squeezed juice on carrageenan induced rat paw edema.
Front. Pharmacol.
Conference Abstract:
International Conference on Drug Discovery and Translational Medicine 2018 (ICDDTM '18)
“Seizing Opportunities and Addressing Challenges of Precision Medicine”.
doi: 10.3389/conf.fphar.2019.63.00024
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Received:
29 Nov 2018;
Published Online:
17 Jan 2019.
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Correspondence:
Dr. Syarief Hudaya, Universitas Wahid Hasyim, Semarang, Central Java, Indonesia, drsyariefhudaya@yahoo.co.id