Effective connectivity in face processing, as inferred from MEG, EEG and fMRI data
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1
Cognition and Brain Sciences Unit, Medical Research Council (MRC), United Kingdom
The spatial and temporal neural correlates of human face-processing have been well-studied with haemodynamic and electrophysiological techniques; however, less is known about how such processing is supported by changes in connectivity between key brain regions like the OFA, FFA and STS [1]. We used an established paradigm that isolates the key processes of face perception, recognition and priming [2]. Images of 150 famous, 150 unfamous, and 150 scrambled images were presented in a pseudo-random order, in which each image was repeated either immediately or 5-15 images later. MEG and EEG data were acquired using an Elekta Neuromag Vectorview (70 EEG channels) on 16 participants. The same paradigm (but with different images of the faces) was repeated on the same participants while acquiring functional MRI data. Structural MRI data included a T1 and two multi echo FLASH sequences, enabling creation of accurate 3 layer BEMs. Analysis of the MEG and EEG data show several robust effects: a M/N170 to faces versus scrambled images (face perception); a M/N250r for initial versus immediately repeated famous faces (priming); and an effect around 500ms for famous faces versus unfamous faces (recognition). The fMRI data revealed OFA, FFA and STS regions, among others, which were generally associated with face perception and repetition. These regions can be used as nodes in a network model (for example, Dynamic Causal Modelling) to study how effective connectivity between them changes over milliseconds, giving rise to the temporally-distinct MEG/EEG signatures. More generally, this multimodal dataset would seem an ideal source for studying functional connectivity between regions in an well-established visual processing system.
References
1. Haxby et al. The distributed human neural system for face perception. Trends Cogn Sci 4, 223-233 (2000).
2. Henson et al. Electrophysiological and haemodynamic correlates of face perception, recognition and priming. Cerebral Cortex, 13, 793-805 (2003).
Conference:
Biomag 2010 - 17th International Conference on Biomagnetism , Dubrovnik, Croatia, 28 Mar - 1 Apr, 2010.
Presentation Type:
Poster Presentation
Topic:
Neurocognition and Functional Connectivity
Citation:
Wakeman
DG and
Henson
R
(2010). Effective connectivity in face processing, as inferred from MEG, EEG and fMRI data.
Front. Neurosci.
Conference Abstract:
Biomag 2010 - 17th International Conference on Biomagnetism .
doi: 10.3389/conf.fnins.2010.06.00404
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Received:
08 Apr 2010;
Published Online:
08 Apr 2010.
*
Correspondence:
Daniel G Wakeman, Cognition and Brain Sciences Unit, Medical Research Council (MRC), Cambridge, United Kingdom, daniel.wakeman@mrc-cbu.cam.ac.uk