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Spatial synchronization structure of field potentials and spikes in a delayed grip task

Michael Denker1*, Thomas Brochier2, Alexa Riehle2 and Sonja Gruen1, 3
  • 1 Forschungszentrum Juelich, Institute of Neuroscience and Medicine (INM-6), Germany
  • 2 CNRS - Univ. Aix-Marseille 2, Mediterranean Institute of Cognitive Neuroscience (INCM), France
  • 3 RIKEN Brain Science Institute, Laboratory for Statistical Neuroscience, Japan

Modulations of the local field potential (LFP) are commonly attributed to the synchronization of inputs received by neurons in the vicinity of the recording electrode. Moreover, the LFP is shown to relate to firing rates and the degree of correlation exhibited by nearby neurons [1], establishing the LFP as an excellent monitor of the coordinated neuronal population activity. In primary motor (MI) and premotor (PM) cortical areas, during an instructed delay LFPs typically show oscillatory activity mostly restricted to the beta-range (15–30Hz). However, although it is demonstrated that beta activity exhibits in general a wave-like propagation across the motor cortical surface [2], little is known about how such spatially structured synchronization observed on the population level relates to the organization of task-related spike synchronization on the millisecond time scale [3]. We aim to compare these two levels of correlated activity, extending our previous results relating population dynamics to spike synchrony [4].
In short, two monkeys were trained to press a switch with one hand, and then to pull an object using either a Side Grip or a Precision Grip. The object is either heavy or light. To allow the monkey to prepare the upcoming movement, the grip type was revealed to the monkey preceding a delay period of 1s before the GO signal. Massively parallel LFP and spiking activity was recorded using a 100 electrode array implanted at the MI/PMd border.
Here, we analyze beta oscillations during the preparatory phase with respect to the two grip types and cortical location. Based on the spectral coherency and the degree of phase synchrony across electrodes, we show the spatial inhomogeneity of LFP wave propagation direction and speed. In parallel, we compute the pair-wise significant spike correlations [3] between single unit activities as a function of spatial and directional parameters. Lastly, these results are complemented with the map of features extracted from the movement-related potentials observed upon movement execution.

Acknowledgements

Riken BSI, Helmholtz Alliance on Systems Biology, DAAD, Neuro_IC2010, CNRS-PEPS.

References

[1] Okun M, Lampl I (2008) Nat Neurosci 11: 535-537. Lindén H, Pettersen KH, Tetzlaff T, Potjans T, Denker M, Diesmann M, Grün S, Einevoll GT (2009) BMC Neuroscience 10(Suppl 1): P224.
[2] Rubino D, Robbins KA, Hatsopoulos NG (2006) Nat Neurosci 9: 1549-1557.
[3] Grün S., Diesmann M, Aertsen A (2002) Neural Comp, 14: 81-119.
[4] Denker M, Roux S, Linden H, Diesmann M, Riehle A, Grün S (2011) Cerebral Cortex: adv. online.

Keywords: Correlation, LFP, motor control, synchronization

Conference: BC11 : Computational Neuroscience & Neurotechnology Bernstein Conference & Neurex Annual Meeting 2011, Freiburg, Germany, 4 Oct - 6 Oct, 2011.

Presentation Type: Poster

Topic: motor control (please use "motor control" as keyword)

Citation: Denker M, Brochier T, Riehle A and Gruen S (2011). Spatial synchronization structure of field potentials and spikes in a delayed grip task. Front. Comput. Neurosci. Conference Abstract: BC11 : Computational Neuroscience & Neurotechnology Bernstein Conference & Neurex Annual Meeting 2011. doi: 10.3389/conf.fncom.2011.53.00103

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Received: 23 Aug 2011; Published Online: 04 Oct 2011.

* Correspondence: Dr. Michael Denker, Forschungszentrum Juelich, Institute of Neuroscience and Medicine (INM-6), Juelich, 52425, Germany, m.denker@fz-juelich.de