Mesoporous silica nanospheres with multifunctional properties for bone regeneration
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1
Institute of Health and Biomedical Innovation, Queensland University of Technology, Australia
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2
Shanghai Institute of Ceramics, Chinese Academy of Sciences, China
Introduction: Multifunctional bioactive materials for the reconstruction of bone defects have attracted intensive research interest in recent years[1]. Bone regeneration requires a series of coordinated events involving angiogenesis and osteogenesis, it is therefore pivotal to design a biomaterial system which can simultaneously stimulate blood vessel growth and bone formation in order to repair large bone defects. The aim of the present study is to develop a multifunctional biomaterial system for scaffolding and therapeutic ions/drug delivery to promote neovascularization of tissue-engineered bone constructs.
Materials and Methods: Mesoporous silica nanospheres (MSNs) with uniform sphere size and mesopores were successfully fabricated, which could release therapeutic silicon ions (Si). Dimethyloxaloylglycine (DMOG)[2], a chemical hypoxia mimetic, was loaded in the mesopores of MSNs (D-MSNs). The stimulatory effects of Si ions and DMOG on both the osteogenic and angiogenic activity of bone marrow stromal cells (BMSCs) were systematically investigated in gene and protein levels.
Results: The sustained release of DMOG from D-MSNs could induce a hypoxic microenvironment, which greatly enhanced the secretion of vascular endothelial growth factor (VEGF) from BMSCs. Furthermore, the Si ions released from the nanospheres significantly increased the expression of osteogenic markers (OCN, RUNX2 and OPN) of BMSCs.
Discussion: D-MSN, serving as both Si ion reservoir and drug carrier, has the capacity to promote bone regeneration and induce blood vessel formation[3],[4]. This suggests that D-MSN is a promising candidate as a multifunctional biomaterial system for bone tissue engineering application.
Conclusion: The concept of delivering both therapeutic ions and functional drugs in a multifunctional biomaterial system may offer a new strategy to construct functional tissue-engineered bone.
References:
[1] Multifunctional mesoporous bioactive glasses for effective delivery of therapeutic ions and drug/growth factors.
[2] Delivery of dimethyloxallyl glycine in mesoporous bioactive glass scaffolds to improve angiogenesis and osteogenesis of human bone marrow stromal cells.
[3] Silicon-substituted calcium phosphates – a critical view.
[4] Critical role of hypoxia sensor-HIF-1a in VEGF gene activation. Implications for angiogenesis and tissue injury healing.
Keywords:
Bone Regeneration,
Tissue Engineering,
blood vessel
Conference:
10th World Biomaterials Congress, Montréal, Canada, 17 May - 22 May, 2016.
Presentation Type:
Poster
Topic:
Biomaterials in constructing tissue substitutes
Citation:
Zhou
Y,
Shi
M,
Shao
J,
Chen
Z,
Song
B,
Chang
J,
Wu
C and
Xiao
Y
(2016). Mesoporous silica nanospheres with multifunctional properties for bone regeneration.
Front. Bioeng. Biotechnol.
Conference Abstract:
10th World Biomaterials Congress.
doi: 10.3389/conf.FBIOE.2016.01.01295
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Received:
27 Mar 2016;
Published Online:
30 Mar 2016.
*
Correspondence:
Dr. Yinghong Zhou, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia, Email1