Osteoimmunomodulation for the development of advanced bone biomaterials
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1
Queensland University of Technology, Institute of Health and Biomedical Innovation, Australia
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2
Chinese Academy of Sciences, Shanghai Institute of Ceramics, China
As direct effector cells for osteogenesis, osteoblasts are commonly used for the evaluation of osteogenic inductivity and osteoconductivity of biomaterials in vitro. This is based on the traditional biological principle for developing bone biomaterials, which is to stimulate osteogenic differentiation of mesenchymal stem cells. With this principle, most of the efforts are currently spent on optimising the bio-mechanical and physicochemical properties to induce osteogenic differentiation of mesenchymal stem cells. This strategy has achieved certain success in the development of bone biomaterials; however, inconsistencies between in vitro and in vivo studies are not uncommon, implying the mechanisms that govern the material's capacity to mediate osteogenesis is not well-understood. Osteoimmunology has revealed the vital role of immune cells in regulating bone dynamics. Neglecting the importantance of the immune response is a major shortcoming of the current design for bone biomaterials. We proposed osteoimmunomodulation is critical in developing bone biomaterials and developed unique in vitro biomaterials assessment assays to assist in materials design. The project will significantly improve the development of the next generation of bone biomaterials with osteoimmunomodulatiory peoperty for orthopaedic and dental applications.
Keywords:
Bioactivity,
material design,
biofunctionalization,
Bone graft
Conference:
10th World Biomaterials Congress, Montréal, Canada, 17 May - 22 May, 2016.
Presentation Type:
New Frontier Oral
Topic:
Biomaterials in immune response
Citation:
Xiao
Y,
Chen
Z,
Chang
J and
Wu
C
(2016). Osteoimmunomodulation for the development of advanced bone biomaterials.
Front. Bioeng. Biotechnol.
Conference Abstract:
10th World Biomaterials Congress.
doi: 10.3389/conf.FBIOE.2016.01.00215
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Received:
28 Mar 2016;
Published Online:
30 Mar 2016.