Dissecting the Genetic and Environmental Relationship between Schizophrenia and Duration MMN
-
1
Cognitive Neuroscience Laboratory, McLean Hospital,Department of psychiatry, Harvard Medical School, United States
-
2
Division of Psychological Medicine, Institute of Psychiatry, King's College London, United Kingdom
-
3
Department of Psychiatry, University of Hong Kong, China
Mismatch negativity (MMN) has been proposed as a potential endophenotype for schizophrenia. For a trait to be an appropriate endophenotype, several key features should exist. We used a twin study design and structure equation modeling analyses to evaluate whether duration MMN meets criteria as a valid endophenotype of schizophrenia.
Results of our studies suggested that duration MMN is heritable (estimated heritability h2 = .48). However, significant individual specific environmental factors (c2 = .30) also contribute to the total variance. Patients with schizophrenia had significantly reduced MMN amplitude. No significant impairments were observed in the unaffected co-twin members of schizophrenic twin pairs. Genetic model fitting analyses indicated that there existed a significant correlation between duration MMN amplitude and schizophrenia but the decomposed genetic effect of MMN with the disease appeared to be weak. Thus, our results suggested that duration MMN may not be an optimal paradigm for facilitating gene discovery of schizophrenia. Instead, it may be used as a strategy for providing information about the biological mechanisms underlying neuronal abnormalities during illness progression.
Conference:
MMN 09
Fifth Conference on Mismatch Negativity (MMN) and its Clinical and Scientific Applications, Budapest, Hungary, 4 Apr - 7 Apr, 2009.
Presentation Type:
Oral Presentation
Topic:
Symposium 1: MMN as a potential endophenotype in schizophrenia
Citation:
Hall
MH,
Scherer
K,
Rijsdijk
F,
Picchioni
M,
Ettinger
U,
Bramon
E,
Murray
RM and
Sham
P
(2009). Dissecting the Genetic and Environmental Relationship between Schizophrenia and Duration MMN.
Conference Abstract:
MMN 09
Fifth Conference on Mismatch Negativity (MMN) and its Clinical and Scientific Applications.
doi: 10.3389/conf.neuro.09.2009.05.038
Copyright:
The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers.
They are made available through the Frontiers publishing platform as a service to conference organizers and presenters.
The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated.
Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed.
For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions.
Received:
20 Mar 2009;
Published Online:
20 Mar 2009.
*
Correspondence:
Mei H Hall, Cognitive Neuroscience Laboratory, McLean Hospital,Department of psychiatry, Harvard Medical School, Massachusetts, United States, mhall@mclean.harvard.edu