The differences in brain mechanism for motor inhibition in patients with cerebral palsy: an fMRI study
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1
Yonsei University, Republic of Korea
Cerebral palsy (CP) is one of the most developmental neuropathies occured during the delivery. Even there was great advance in prevention and treatment of CP, the result of this disorder needs life-long care. Most of CP was caused by periventricular leukomalacia(PVL) with vast neuronal cell death around ventricular region. Even brain damage causes wide cognitive deficit in movement, however, recent research did not find etiological factors of this damage. Movement inhibition is one of the core factors in regulating movement. Among various region for this mechanism, SMA is well known for regulating error-related response and movement control. For investigating the functional feature on this area, Go-Nogo task was widely used in many previous reports. Using one nine-minute, event-related Go-Nogo taks, we performed functional magnetic resonance imaging study between patients with cerebral palsy and healthy controls Functional images were obtained using high-resolution 3T MRI scanner (IntraAchieva, Phillips medical system, Best, The Netherlands). Acquired images underwent preprocessing and analysis using statistical parametric mapping toolbox (SPM2, Welcome Department of Cognitive Neurology, UCL, UK). After individual analysis, we performed t tests for group analysis. Also we measured roi-based percentage of signal change in the brain area, which had shown difference in brain activity between two groups For the result, we found the difference in brain activation on bilateral supplementary motor area (BA 6) and anterior cingulate cortex (BA 32) during Nogo vs. Go condition. Also there was negative BOLD signal on these areas In conclusion, the differences in the brain activation are considered as a result of brain damage. Especially, the negative BOLD signal was known to be related with GABA-ergic effect on the brain areas. Therefore, these results will be thought to have reationship with behavioral disorder in patients with cerebral palsy. For the further study, biological markups on these areas using other neuroimaging techniques are required.
Conference:
10th International Conference on Cognitive Neuroscience, Bodrum, Türkiye, 1 Sep - 5 Sep, 2008.
Presentation Type:
Poster Presentation
Topic:
Neuropsychiatric Disorders
Citation:
Park
H,
Seo
B and
Lee
J
(2008). The differences in brain mechanism for motor inhibition in patients with cerebral palsy: an fMRI study.
Conference Abstract:
10th International Conference on Cognitive Neuroscience.
doi: 10.3389/conf.neuro.09.2009.01.390
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Received:
17 Dec 2008;
Published Online:
17 Dec 2008.
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Correspondence:
H.J Park, Yonsei University, Seoul, Republic of Korea, seo307@gmail.com