Differential activation of neural networks as a function of correct or incorrect responses in a recognition memory task
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1
Universite Claude-Bernard Lyon1, Neurosciences Sensorielles, Comportement & Cognition, France
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2
INRA UMR, France
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3
San Diego State University, United States
Memory’s distorsions are not restricted to forgetting. Memory can be present, but incorrect. The present study aimed to shed light on the neural substrates activated during correct and incorrect responses in an odor recognition memory task in healthy subjects. We also examined olfactory processes differentially associated with correct and incorrect responses as a function of age by testing young and old subjects. Sixteen young (27.1 y.o.) and 22 elderly (68.4 y.o.) subjects participated in the study. Odors were presented in synchronization with the subject's inspiration according to an event-related fMRI design. Fifty odors were presented during a first run during which subjects performed a detection task, and 100 odors (50 old and 50 new odors) were presented during a second run, during which subjects performed a recognition task. Performance was coded with hits, misses, correct rejections (CR) and false alarms (FA). fMRI images were analysed using Statistical Parametrical Mapping, and Regions of Interest analysis (piriform cortex, amygdala, hippocampus (Hip), parahippocampal (PH), perirhinal and entorhinal cortices).
Activation was higher when responses were incorrect (Miss, FA) than correct (Hit, CR) in several areas including the prefrontal cortex, cingulate gyrus, insula, putamen, thalamus, perirhinal and entorhinal cortices. Inversely, activation was higher when responses were correct than incorrect in the Hip and PH area. Regarding the age effect, memory performance was higher in young than old subjects, but no bias difference was found between both groups. Activation was higher in the old than in the young subjects in the Hip and the PH area, whereas it was higher in the young than in the old subjects in the dorsal cingulate and right anterior insula. Results were discussed in relation to the functional organization of the medial temporal system and the degree of subjective confidence of subjects, possibly related to the number of odors presented.
Conference:
41st European Brain and Behaviour Society Meeting, Rhodes Island, Greece, 13 Sep - 18 Sep, 2009.
Presentation Type:
Poster Presentation
Topic:
Poster presentations
Citation:
Royet
J,
Leri
M,
Barbara
C,
Lori
H,
Sylvie
I,
Claire
M and
Claire
S
(2009). Differential activation of neural networks as a function of correct or incorrect responses in a recognition memory task.
Conference Abstract:
41st European Brain and Behaviour Society Meeting.
doi: 10.3389/conf.neuro.08.2009.09.281
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Received:
12 Jun 2009;
Published Online:
12 Jun 2009.
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Correspondence:
Jean-Pierre Royet, Universite Claude-Bernard Lyon1, Neurosciences Sensorielles, Comportement & Cognition, Lyon, France, jean-pierre.royet@cnrs.fr