Characterization of lipocalin 2 ontogenic expression profile
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1
School of Health Sciences, University of Minho, Life and Health Sciences Research Institute, Portugal
Iron homeostasis in the body is tightly regulated. Involved in the regulation of iron are several proteins such as transferrin, ferritin and lipocalin 2 (LCN2). While LCN2 is mostly studied given its ability to sequester bacteria iron loaded siderophores, other functions have been discussed in the context of its physiological role, particularly with respect to iron delivery to tissues, namely the brain. Of interest is the differentially regulated expression of transferrin, the well characterized and recognized transporter of iron into cells, during development. In this work we describe the LCN2 expression pattern throughout fetal development and in early stages of adult growth under normal/control (saline injection) and in response to peripheral inflammation. Preliminary data show that, in the embryo, LCN2 is mainly expressed in the liver and that is not further expressed in response to LPS; in the adult LCN2 i) is expressed in the kidney, spleen, thymus and liver in both saline and LPS treated conditions, with higher expression in the later condition and ii) in the brain LCN2 is expressed in the CP and endothelial cells of the blood brain barrier only upon LPS treatment.
Conference:
11th Meeting of the Portuguese Society for Neuroscience, Braga, Portugal, 4 Jun - 6 Jun, 2009.
Presentation Type:
Poster Presentation
Topic:
Barriers of the Brain
Citation:
Cruz
R,
Marques
F,
Mendanha-Falcao
A,
Correia-Neves
M,
Almeida-Palha
J and
Sousa
JC
(2009). Characterization of lipocalin 2 ontogenic expression profile.
Front. Neurosci.
Conference Abstract:
11th Meeting of the Portuguese Society for Neuroscience.
doi: 10.3389/conf.neuro.01.2009.11.034
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Received:
06 Aug 2009;
Published Online:
06 Aug 2009.
*
Correspondence:
Joao C Sousa, School of Health Sciences, University of Minho, Life and Health Sciences Research Institute, Braga, Portugal, jcsousa@med.uminho.pt