Similarities of electrical stimulation induced slow oscillation in different vigilance states in epileptic patients.
Laszlo
Entz1, 2*,
Daniel
Fabo1, 2,
L.
Eross2,
P.
Halasz3,
Lucia
Wittner1,
G.
Karmos1, 3 and
I.
Ulbert1, 2, 3
-
1
Institute for Psychology, Hungarian Academy of Sciences, Hungary
-
2
National Institute of Neurosurgery, Hungary
-
3
Péter Pázmány Catholic University, Hungary
Cortical electrical stimulation in epilepsy surgery is broadly used for functional mapping of the underlying cortex and also for seizure focus localization. Recently, scalp EEG studies showed that transcranial electrical (TES) and magnetic stimulation (TMS) can trigger Slow Oscillation (SO) in deeper stages of non-REM sleep, but not in wakefulness. In order to investigate the effect of different vigilance states on triggered SO, single pulse cortical electrical stimulation (CES) was combined with subdural electrocorticography (ECoG) and intracortical laminar recordings in humans. Patients with drug resistant epilepsy were implanted with subdural grid and strip electrodes and intracortical laminar multielectrodes. Brief single current pulses were injected into adjacent grid contacts and responses were averaged both from the grids and the laminar electrodes in awake, sleeping and anesthetized state. We have found that CES awake an initial biphasic activation, which is followed by a single wave of SO, characterized by a long lasting negative ECoG potential (down state) and a rebound positivity (up state) in the close (1-2cm) vicinity of the stimulation electrode, regardless of the vigilance state (sleep, awake and anesthesia) of the patient. Comparing the spatial distribution of the stimulus evoked SO between sleep and wakefulness, our preliminary results showed quite similar extent of activation if stimulated between the same electrode pairs. Regarding the amplitude and latency of the triggered SO, we also find similar values between sleep and wake stimulation. Using high resolution mapping methods, our results suggest that contrary to TMS and TES, CES can initiate a single SO cycle in the close vicinity of the stimulation site even in the waking state.
Conference:
12th Meeting of the Hungarian Neuroscience Society, Budapest, Hungary, 22 Jan - 24 Jan, 2009.
Presentation Type:
Poster Presentation
Topic:
Pathophysiology and neurology - degenerative disorders
Citation:
Entz
L,
Fabo
D,
Eross
L,
Halasz
P,
Wittner
L,
Karmos
G and
Ulbert
I
(2009). Similarities of electrical stimulation induced slow oscillation in different vigilance states in epileptic patients..
Front. Syst. Neurosci.
Conference Abstract:
12th Meeting of the Hungarian Neuroscience Society.
doi: 10.3389/conf.neuro.01.2009.04.149
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Received:
05 Mar 2009;
Published Online:
05 Mar 2009.
*
Correspondence:
Laszlo Entz, Institute for Psychology, Hungarian Academy of Sciences, Budapest, Hungary, entz@gmx.net