Myelination in the developing human hippocampal formation
-
1
University of Pécs, Hungary
-
2
Department of Obstetrics and Gynecology , University of Pecs, Hungary
-
3
Department of Pathology , University of Pecs, Hungary
Myelination, the last step of neuronal development was examined in the human fetal and postnatal hippocampal formation with immunohistochemistry detecting a protein component of the myelin sheath, the myelin basic protein synthetized by oligodendroglial cells (OCs). OCs were detected at the 20th gestational weeks (GW) in the fornix and in alveus adjacent to it. Between the 21th and 35th GW, the first myelinated axons appeared in the fornix. At the age of 39 GW short, thin myelinated fibers were present in the fornix, in the alveus, and to a lesser extent in stratum oriens of the hippocampus while the first OCs were shown in the stratum lacunosum-moleculare and in the hilus. By the 2nd postnatal week the first myelinated fibers appeared in stratum lacunosum-moleculare. At the 3rd month myelination was strong in alveus, moderate in strata oriens, lacunosum-moleculare, radiatum, while small number of myelinated fibres was detected in the hilus. At the 5th month the first OCs were detected in the molecular layer of the dentate gyrus. In the following years, myelination could be followed particularly in the dentate gyrus where even at the age of 11 years the density of myelinated fibers did not reach adult level. The sequence of myelination follows the known developmental pattern of hippocampal afferent and efferent axons, and the prolonged myelination can be a factor of the long-lasting functional maturation of hippocampal circuitry. Supported by OTKA grants #K 047109, by the Bolyai Scholarship to H. Ábrahám.
Conference:
12th Meeting of the Hungarian Neuroscience Society, Budapest, Hungary, 22 Jan - 24 Jan, 2009.
Presentation Type:
Poster Presentation
Topic:
Developmental neurobiology and subcortical functions
Citation:
Vincze
A,
Veszpremi
B,
Kravjak
A,
Gomori
E,
Seress
L and
Ábrahám
H
(2009). Myelination in the developing human hippocampal formation.
Front. Syst. Neurosci.
Conference Abstract:
12th Meeting of the Hungarian Neuroscience Society.
doi: 10.3389/conf.neuro.01.2009.04.081
Copyright:
The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers.
They are made available through the Frontiers publishing platform as a service to conference organizers and presenters.
The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated.
Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed.
For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions.
Received:
02 Mar 2009;
Published Online:
02 Mar 2009.
*
Correspondence:
Hajnalka Ábrahám, University of Pécs, Pecs, Hungary, hajnalka.abraham@aok.pte.hu