Electrophysiological recordings with active microprobe arrays
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1
Hungarian Academy of Sciences, Institute for Psychology, Hungary
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2
University of Freiburg, Department of Microsystems Engineering (IMTEK), Germany
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3
Interuniversity Microelectronics Center (IMEC), Belgium
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4
Pázmány Péter Catholic University, Faculty of Information Technology, Hungary
Neural microprobes are a key technology to understand the fundamental mechanisms of the brain at a cellular level and one of the key tools nowadays used by neuroscientists. A new type of active CMOS based microprobe arrays has been evaluated. These devices implement an electronic depth control system coordinating a large number of electronically switchable recording sites. They significantly increase the amount of information that can be obtained from a single experiment as compared to passive multi-electrode arrays. The 4mm long, single shank probes with 188 recording sites separated by 40 micrometer were attached to a micro manipulator which was used for the insertion. NeuroSelect control software was used to select the best-performing contacts manually through a microcontroller. The results show the potential for electronic depth control and the capability of this type of probe arrays to record good quality local field potentials (LFP), single (SUA) and multiple unit activities (MUA) in different cortical regions of rats during cortical slow oscillation (SO). The relationship between LFP and SUA in down- and up-states of cortical SO has been analyzed with perievent time histograms (PETH) and time-frequency maps were calculated to verify each separated state. Signal to noise ratio was computed and a spike clustering method was used to find the activity of single neurons. We conclude that this methodology is viable for mass recording of neuronal electrical activity.
Keywords:
methods,
Neuroscience
Conference:
13th Conference of the Hungarian Neuroscience Society (MITT), Budapest, Hungary, 20 Jan - 22 Jan, 2011.
Presentation Type:
Abstract
Topic:
Methods
Citation:
Dombovári
B,
Seidl
K,
Herwik
S,
Torfs
T,
Grand
L,
Csercsa
R,
Paul
O,
Neves
HP,
Ruther
P and
Ulbert
I
(2011). Electrophysiological recordings with active microprobe arrays.
Front. Neurosci.
Conference Abstract:
13th Conference of the Hungarian Neuroscience Society (MITT).
doi: 10.3389/conf.fnins.2011.84.00109
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Received:
03 Mar 2011;
Published Online:
23 Mar 2011.
*
Correspondence:
Dr. B. Dombovári, Hungarian Academy of Sciences, Institute for Psychology, Budapest, Hungary, dombovari@cogpsyphy.hu