Role of neurotensin injected into the ventral pallidum in open field and in conditioned place preference test.
-
1
University of Pécs, Institute of Physiology and Neurophysiology Research Group of the Hungarian Academy of Sciences (HAS), Hungary
The ventral pallidum (VP) plays important role in motivation, reward and memory processes. Neurotensin (NT) is a neurotransmitter which can be detected in the VP, but it’s exact behavioral effects in the VP have not been studied yet. In our present experiments we investigated the effects of NT injected bilaterally into the VP in open field (OpF) and in conditioned place preference (CPP) test. In both experiments 100 ng or 250 ng NT (dissolved in 0.4 ml saline) were microinjected into the VP, control animals received only vehicle. In OpF test after a habituation session basal activity was measured, then the general activity after NT microinjection was recorded. The CPP test started with a habituation period, then the microinjection was carried out in three following days. During the test period time spent in treatment quadrant was measured. Neither 100 ng, nor 250 ng of NT influenced the animals’ general activity in OpF test. Hundred ng dose of NT induced CPP: animals spent significantly more time in the treatment quadrant, relative to time measured during habituation and to time recorded in control animals during test. Animals injected with 250 ng NT showed only a tendency to spend more time in the treatment quadrant. Our results show that NT injected into the VP does not influence general activity of the animals but plays important role in place learning and reinforcement processes.
Acknowledgements
Supported by NKTH-OTKA K 68431 and the HAS.
Keywords:
Behaviour and cognition,
Neuroscience
Conference:
13th Conference of the Hungarian Neuroscience Society (MITT), Budapest, Hungary, 20 Jan - 22 Jan, 2011.
Presentation Type:
Abstract
Topic:
Behaviour and cognition
Citation:
Ollmann
T,
Péczely
L,
László
K,
Kovács
A and
Lénárd
L
(2011). Role of neurotensin injected into the ventral pallidum in open field and in conditioned place preference test..
Front. Neurosci.
Conference Abstract:
13th Conference of the Hungarian Neuroscience Society (MITT).
doi: 10.3389/conf.fnins.2011.84.00010
Copyright:
The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers.
They are made available through the Frontiers publishing platform as a service to conference organizers and presenters.
The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated.
Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed.
For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions.
Received:
03 Mar 2011;
Published Online:
23 Mar 2011.
*
Correspondence:
Dr. T. Ollmann, University of Pécs, Institute of Physiology and Neurophysiology Research Group of the Hungarian Academy of Sciences (HAS), Pécs, Hungary, ollmanntamas@gmail.com