Orbitofrontal dysfunction discriminates behavioural variant frontotemporal dementia from Alzheimer disease
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1
Prince of Wales Medical Research Institute, Australia
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2
University of New South Wales, School of Medical Sciences, Australia
Recent studies suggest that behavioural variant frontotemporal dementia (bv-FTD) patients show orbitofrontal dysfunction. We investigated executive function & neural correlates of bv-FTD and Alzheimer (AD) patients to establish diagnostic markers discriminating the two groups. A range of neuropsychological test, as well as T1 based magnetic resonance scan ratings were employed. Mean overlap-based statistical analyses and logistic regression analyses were performed to distinguish bv-FTD from AD cases. AD and bv-FTD patients were distinguishable by their performance on 3 executive neuropsychological tasks: the Hayling test of inhibitory control, Digit Span Backward and Letter Fluency. Logistic regression showed that 89.5% of patients could be classified on the basis of their executive function performance. Similarly, scan ratings showed that orbitofrontal and dorsolateral prefrontal cortex regions distinguish both patient groups. More importantly, employing the Hayling Error Score in conjunction with the orbitofrontal atrophy rating showed that 91.7% of patients can be correctly classified into bv-FTD and AD. Employment of orbitofrontal atrophy measures in combination with objective and quantitative disinhibition measures emerges as one of the most efficient discriminators of bv-FTD and AD, despite reports of similar behavioural complaints. These findings have clear implications for a better diagnosis of bv-FTD and AD.
Conference:
The 20th Annual Rotman Research Institute Conference, The frontal lobes, Toronto, Canada, 22 Mar - 26 Mar, 2010.
Presentation Type:
Poster Presentation
Topic:
Neurologic
Citation:
Hodges
JR and
Hornberger
M
(2010). Orbitofrontal dysfunction discriminates behavioural variant frontotemporal dementia from Alzheimer disease.
Conference Abstract:
The 20th Annual Rotman Research Institute Conference, The frontal lobes.
doi: 10.3389/conf.fnins.2010.14.00146
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Received:
01 Jul 2010;
Published Online:
01 Jul 2010.
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Correspondence:
M. Hornberger, Prince of Wales Medical Research Institute, Sydney, Australia, m.hornberger@powmri.edu.au