Clinical and genetic aspects of spastic paraplegia
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1
Mohamed V – Souissi University, ISB, Morocco
Hereditary spastic paraplegias (HSPs) are a clinically and genetically heterogeneous group of conditions characterized by the presence of lower limb spasticity and weakness. HSP is diagnosed on the basis of characteristic clinical symptoms, neurological examination, family history, or by identification of a pathogenic mutation in an HSP-causing gene. There is currently no cure or specific drug treatment. However new therapies are under investigation and clinical trials are in progress.
Our genetic research and development institution in Morocco has studied 38 families of uncomplicated HSP-AR of the uncomplicated type. The findings confirmed that 3 of the families were related.
Hopefully, future advances will identify other genes associated with HSP, in addition to those already known. This would allow a better understanding of the pathogenic mechanisms underlying the disorder and contribute to the search for new treatments.
Conference:
2nd NEUROMED Workshop, Fez, Morocco, 10 Jun - 12 Jun, 2010.
Presentation Type:
Poster Presentation
Topic:
Poster session 1: Neurodegenerative diseases
Citation:
Benomar
A
(2010). Clinical and genetic aspects of spastic paraplegia.
Front. Neurosci.
Conference Abstract:
2nd NEUROMED Workshop.
doi: 10.3389/conf.fnins.2010.12.00024
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Received:
04 Jun 2010;
Published Online:
04 Jun 2010.
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Correspondence:
Ali Benomar, Mohamed V – Souissi University, ISB, Rabat, Morocco, alibenomar@hotmail.com