Calcitonin-induced sleep disturbance in rat when injected in the lateral ventricle and into the periaqueductal gray
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1
Universite Cadi Ayyad, Laboratoire de Pharmacologie, Neurobiologie et Comportement; Equipe de pharmacologie et Comportement; Faculté des Sciences Semlalia, Morocco
We have previously proposed that behavioral alterations induced by salmon calcitonin in the rat provide an animal model of depression. As depression is often paired with sleep disturbance and both interact in a quite complex manner, we examined the effects of microinjections of salmon calcitonin into the lateral ventricle and into the ventral PAG of the brain on sleep. The electroencephalogram (EEG) and Electromyogram (EMG) were continuously recorded during the first 8 hours postinjection. When injected in the lateral ventricle, calcitonin affect specially the total REM sleep. Calcitonin increases the total time spent in wakefulness, increases total NREM sleep and decreases considerably total REM sleep when injected into the ventral PAG.
Keywords:
Acetylcholine,
Calcitonin,
Memory
Conference:
2nd NEUROMED Workshop, Fez, Morocco, 10 Jun - 12 Jun, 2010.
Presentation Type:
Poster Presentation
Topic:
Poster session 1: Neurodegenerative diseases
Citation:
Aboufatima
R,
Zyad
A,
Hafid
J and
Chait
A
(2010). Calcitonin-induced sleep disturbance in rat when injected in the lateral ventricle and into the periaqueductal gray.
Front. Neurosci.
Conference Abstract:
2nd NEUROMED Workshop.
doi: 10.3389/conf.fnins.2010.12.00023
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Received:
04 Jun 2010;
Published Online:
04 Jun 2010.
*
Correspondence:
A. Chait, Universite Cadi Ayyad, Laboratoire de Pharmacologie, Neurobiologie et Comportement; Equipe de pharmacologie et Comportement; Faculté des Sciences Semlalia, Marrakech, Morocco, chait@ucam.ac.ma