The effect of single episod of maternal deprivation on the hypothalamo-pituitary-adrenal axis regulation in vasopressin deficient Brattleboro rats
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1
Hungarian Academy of Sciences, Institute of Experimental Medicine, Hungary
Early life events have special importance in the development of long term alterations, among others in the hypothalamo-pituitary-adrenal (HPA) axis controlled stress processes. We already proved that during the perinatal period vasopressin (AVP) is the main hypothalamic regulator of the HPA axis. Here we addressed the question if the lack of AVP in Brattleboro rats will modify not only the immediate but also the later consequences of perinatal stress.
AVP-producing (di/+) and deficient (di/di) Brattleboro rat were used. In 10-day-old pups the 24h maternal separation induced a remarkable corticosterone elevation in both genotypes without ACTH increase in di/di rats. In adult rats those, that were maternally separated for 24h in their 10-day-old age showed some tendencies for a chronic stress state, which were not so obvious in AVP-deficient animals. Studying the shorter consequences of maternal deprivation at around weaning (in 25-35 days old rat) we found stronger effects with significant role of AVP.
As summary during the postnatal period the ACTH elevation to maternal separation was abolished in the absence of AVP and alternative secretagogues of glucocorticoids may become in highlight. Single maternal separation did not induce profound long term changes suggesting that lifetime compensation might overcome the effect of perinatal stimuli. The role of AVP in the development of chronic stress due to perinatal changes was confirmed by examination of earlier consequences around weaning.
Conference:
IBRO International Workshop 2010, Pécs, Hungary, 21 Jan - 23 Jan, 2010.
Presentation Type:
Poster Presentation
Topic:
Homeostatic and neuroendocrine systems
Citation:
Stocker
BG,
Barna
I,
Mergl
Z and
Zelena
D
(2010). The effect of single episod of maternal deprivation on the hypothalamo-pituitary-adrenal axis regulation in vasopressin deficient Brattleboro rats.
Front. Neurosci.
Conference Abstract:
IBRO International Workshop 2010.
doi: 10.3389/conf.fnins.2010.10.00131
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Received:
28 Apr 2010;
Published Online:
28 Apr 2010.
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Correspondence:
Bernhard G Stocker, Hungarian Academy of Sciences, Institute of Experimental Medicine, Budapest, Hungary, bernhard.stocker@web.de