Interleukin 6 receptor alpha is expressed in the melanin-concentrating hormone-containing neurons of the human hypothalamus
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1
Institute of Experimental Medicine Hungarian Academy of Sciences, Department of Endocrine Neurobiology, Hungary
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2
Semmelweis University, Department of Anatomy, Histology and Embryology, Hungary
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3
The Sahlgrenska Academy at the University of Gothenburg, Institute of Neuroscience and Physiology/Endocrinology, Sweden
IL-6 deficient mice develop mature onset obesity. Furthermore, intracerebroventricular administration of IL-6 increases energy expenditure suggesting that IL-6 centrally regulates energy homeostasis. To understand the mechanism, how IL-6 may influence the energy homeostasis in humans, we have mapped the distribution of the receptor of IL-6 (IL-6Rα) in the human hypothalamus.
IL-6Rα-immunoreactivity was observed in neuronal perikarya. The IL-6Rα-immunoreactive (IR) neurons located caudal to the level of foramen Monroi. In the most anterior part of the IL-6Rα-IR cell group, only scattered IL-6Rα-IR neurons were located ventrolateraly from the fornix in the lateral hypothalamic area. In more caudal areas, the density of the IL-6Rα-IR neurons gradually increased and these cells occupied the perifornical, lateral and dorsal hypothalamic areas and the hypothalamic dorsomedial nucleus. In the most caudal part of the hypothalamus, scattered IL-6Rα-IR neurons were found in the posterior hypothalamic area. IL-6Rα-immunoreactivity was absent from important vegetative centers like the infundibular nucleus and the hypothalamic paraventricular nucleus.
This distribution is reminiscent to the localization of the melanin concentrating hormone (MCH) and orexin neurons.
Double-labeling immunofluorescent studies demonstrated that all IL-6Rα-IR neurons also contained MCH-immunoreactivity, but the IL-6Rα-IR and orexin B-IR neurons formed separate populations.
Our data demonstrate that the MCH neurons of the human hypothalamus can sense the changes of IL-6 levels suggesting that the effects of IL-6 on energy expenditure are mediated by the MCH neurons in humans.
Conference:
IBRO International Workshop 2010, Pécs, Hungary, 21 Jan - 23 Jan, 2010.
Presentation Type:
Poster Presentation
Topic:
Homeostatic and neuroendocrine systems
Citation:
Fekete
C,
Egri
P,
Füzesi
T,
Palkovits
M,
Liposits
Z,
Gereben
B and
Jansson
J
(2010). Interleukin 6 receptor alpha is expressed in the melanin-concentrating hormone-containing neurons of the human hypothalamus.
Front. Neurosci.
Conference Abstract:
IBRO International Workshop 2010.
doi: 10.3389/conf.fnins.2010.10.00085
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Received:
22 Apr 2010;
Published Online:
22 Apr 2010.
*
Correspondence:
Csaba Fekete, Institute of Experimental Medicine Hungarian Academy of Sciences, Department of Endocrine Neurobiology, Budapest, Hungary, feketecs@koki.hu