Development of nonhuman primate arrhythmia model by magnetocardiography
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1
National Institute of Biomedical Innovation, Japan
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2
Hitachi Ltd., Advanced Research Laboratory, Japan
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3
National Institute of Biomedical Innovation, Tsukuba Primate Research Center, Japan
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4
University of Okayama, Department of Electrical and Electronic Engineering, Japan
Cardiovascular disease (CVD) such as arrhythmia is the leading cause of human morbidity and mortality. The close phylogenetic relationship of cynomolgus monkeys to humans has resulted in their widespread use as a preclinical model of CVD. Therefore, nonhuman primate models of CVD are required that reliably mimic human diseases so that causative mechanisms can be investigated and novel drugs, diagnostic procedures and therapies can be developed. Magnetocardiography (MCG) is a new modality that utilizes superconducting quantum interference devices to detect and visualize weak cardiac electrical activation. The advantages of MCG are high sensitivity to small signals, lack of influence by body tissues and noninvasive recording of signals. The present study highlights the development of the nonhuman primates arrhythmia model using MCG system. We designed an MCG system for nonhuman primates using 64-channel gradiometers in a shielded room with an animal monitoring system. We obtained MCG data from cynomolgus monkey breeding colony at the Tsukuba Primate Research Center. The MCG data were generated as images of averaged waveforms and magnetic field maps. We collected normal images of averaged waveforms and magnetic field maps equivalent to those of humans and established a means of electrophysiological cardiac evaluation in nonhuman primates. This MCG system and normal image will support studies of nonhuman primate models for arrhythmia. We also extracted MCG images reflecting symptoms of arrhythmias such as bundle branch block, long QT syndrome, WPW syndrome and Brugada syndrome in cynomolgus monkey. Establishing these models of arrhythmia in nonhuman primates might be particularly useful for understanding the biological aspects of cardiology. In summary, electrophysiological cardiac evaluation systems based on MCG that can evaluate nonhuman primate CVD will lead to novel models of safety assessment.
Conference:
Biomag 2010 - 17th International Conference on Biomagnetism , Dubrovnik, Croatia, 28 Mar - 1 Apr, 2010.
Presentation Type:
Poster Presentation
Topic:
MCG: Instrumentation, Modeling, Basic and Clinical Studies
Citation:
Ageyama
N,
Seki
Y,
Kandori
A,
Kato
M,
Tsukada
K,
Terao
K and
Yasutomi
Y
(2010). Development of nonhuman primate arrhythmia model by magnetocardiography.
Front. Neurosci.
Conference Abstract:
Biomag 2010 - 17th International Conference on Biomagnetism .
doi: 10.3389/conf.fnins.2010.06.00343
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Received:
07 Apr 2010;
Published Online:
07 Apr 2010.
*
Correspondence:
Naohide Ageyama, National Institute of Biomedical Innovation, Tsukuba, Japan, ageyama@nibio.go.jp