Motor-related areas are activated in response to auditory omission stimuli during simple motor reaction paradigm
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1
Sapporo Medical University, Department of System Neuroscience, Japan
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2
Sapporo Medical University, Department of Neurology, School of Medicine, Japan
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3
Sapporo Medical University, Department of Occupational Therapy, School of Health Science, Japan
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4
Hokkaido University School of Medicine, Department of Pediatrics, Japan
Purpose: To clarify the cerebral processing of motor response mechanism to anticipatory auditory stimuli as well as to unexpected omission to the tone by using magnetoencephalography. Method: Five healthy volunteers were participated. Omission auditory stimuli: Auditory tone burst were presented through auditory air tube binaurally in fixed interval of 700 ms stimulus onset asynchrony. In the auditory sequence, 20% of the stimuli were omitted randomly. Paradigm:1. ACTIVE condition. In a train of auditory stimuli, subjects were requested to move their right thumb in response to the tones as quickly as possible. Subjects should not move their thumb when tones would be omitted. 2. PASSIVE condition. Subjects were just requested to listen to the same stimulus. Recording: Whole-head 204 Ch planar gradiometers (Neuromag Vectorview) was used. Sampling frequency was 600 Hz and bandpass filter was set to 0.10-200Hz. Surface EMG of right thenar muscle and EOG were simultaneously recorded. Two average waveforms (A: responses to auditory stimuli just before omission, B: responses to stimulus omission) were obtained in a session. Average window was set to 100 ms before and 700 ms after the stimulus onset. One session lasted for around 5 min, and 60-70 sweeps were averaged for both auditory and omission in a session. Two sessions were recorded for each condition to confirm reproducibility. Results: In PASSIVE condition, all subjects showed clear auditory M100 activity in response to auditory tones, and dull-shaped, slowly rising component peaking at 100-300 ms at the bilateral temporal regions. In ACTIVE condition, auditory-motor responses were seen at bilateral temporal and the left central area which likely corresponded to motor areas contralateral to the movement. As in the PASSIVE condition, waveform to omission was obtained in all subjects. The responses were clearly seen at the bilateral temporal and the left central area. Conclusion: In the present study, responses for the tone omission in PASSIVE condition were in line of the previous findings. Furthermore, the motor-related areas were actively involved without movements if prepared movements had to be suspended in ACTIVE condition.
Conference:
Biomag 2010 - 17th International Conference on Biomagnetism , Dubrovnik, Croatia, 28 Mar - 1 Apr, 2010.
Presentation Type:
Poster Presentation
Topic:
Sensory Processing and Functional Connectivity
Citation:
Yazawa
S,
Murahara
T,
Sugiura
K,
Ishiguro
M,
Toyoshima
T,
Takeda
S,
Shiraishi
H and
Nagamine
T
(2010). Motor-related areas are activated in response to auditory omission stimuli during simple motor reaction paradigm.
Front. Neurosci.
Conference Abstract:
Biomag 2010 - 17th International Conference on Biomagnetism .
doi: 10.3389/conf.fnins.2010.06.00158
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Received:
26 Mar 2010;
Published Online:
26 Mar 2010.
*
Correspondence:
Shogo Yazawa, Sapporo Medical University, Department of System Neuroscience, Sapporo, Japan, s-yazawa@sapmed.ac.jp