The rat SCO responsiveness to prolonged water deprivation: Implication of Reissner’s fiber and serotonin system
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1
Faculty of Science Semlalia, Cadi Ayyad University, Neuroscience Laboratory, Morocco
The osmotic stress is a potent stimulus that can trigger several peripheral as well as central impairments. The brain is a vulnerable target of the osmotic stress and particularly circumventricular organs (CVOs) regarding their strategic localization as sensory organs of biochemical changes in the blood and cerebrospinal fluid circulations. The subcommissural organ (SCO) is a CVO which releases doubly in the CSF and blood circulation a glycoprotein called Reissner’s fiber (RF) that has been associated to several functions including electrolyte and water balances. The present work was aimed on the assessment of the secretory activity of the SCO and its serotoninergic innervation following 2 weeks of total water restriction in Wistar rat. Using the immunohistochemistry of RF and serotonin (5HT), our data showed a significant overall reduction of RF immunoreactivity within both ependymal and hypendymal cells of the SCO of dehydrated rats compared to their corresponding controls, this decrease was concomitant with an enhancement of fibers 5HT immunoreactivity in the SCO as well as in the classical ependyma and in the dorsal raphe nucleus (DRN), constituting the origin of this innervation. The present findings support the possible involvement of the SCO in the response to prolonged water deprivation by decreasing its secretory materials which may result from either a direct peripheral hormonal control and/or the consequence of the enhanced 5HT innervation of the SCO.
Acknowledgements
This work has been supported by the Moroccan CNRST (SC. Vie 05/10), le Centre national d’e´ tudes et de recherches sur le Sahara (CNERS); OTAN (PDD [CP] - [LST.CLG979823]).
Keywords:
rat,
Dehydration,
Serotonin (5HT),
Reissner’s fiber (RF),
Immunohistochemistry.
Conference:
4th Conference of the Mediterrarnean Neuroscience Society, Istanbul, Türkiye, 30 Sep - 3 Oct, 2012.
Presentation Type:
Poster Presentation
Topic:
Abstracts
Citation:
CHATOUI
H,
El Hiba
O,
Elgot
A and
GAMRANI
H
(2013). The rat SCO responsiveness to prolonged water deprivation: Implication of Reissner’s fiber and serotonin system.
Conference Abstract:
4th Conference of the Mediterrarnean Neuroscience Society.
doi: 10.3389/conf.fnhum.2013.210.00015
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Received:
28 Mar 2013;
Published Online:
11 Apr 2013.
*
Correspondence:
Dr. Hicham CHATOUI, Faculty of Science Semlalia, Cadi Ayyad University, Neuroscience Laboratory, Marrakesh, 40000, Morocco, Chatouih@yahoo.fr