IMPAIRMENT OF MEMORY FORMATION, CONSOLIDATION AND RETRIEVAL OF INHIBITORY AVOIDANCE TASK IN ACUTE MITRAGYNINE-TREATED RATS
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1
Universiti Sains Malaysia, Centre for Drug Research, Malaysia
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2
Universitatsklinikum Erlangen, Psychiatrische und Psychotherapeutische Klinik, Germany
Mitragynine, the major alkaloid compounds of Mitragyna speciosa Korth from Rubiaceae family has been widely used throughout Southeast Asian countries to enhance tolerance for working under scorching sun, to reduce pain sensation and as an alternative for treating morphine addicts. However, the availability of scientific information regarding the cognitive functions is scarce. Hence, the present study aims to investigate the effects of acute mitragynine administration on different stages of learning and memory processes called memory formation, consolidation and retrieval in inhibitory avoidance task. Male Sprague-Dawley rats (180-250 g) were given pre-training, post-training or pre-test intraperitoneal administration of mitragynine at different doses (1, 5 and 10 mg/kg) and tested for passive avoidance task (footshock: 0.5mA, 10 s). Step-through latency (s) was taken as a measure of retention score. The results showed similarity in memory formation, consolidation and retrieval process. Mitragynine significantly reduces the step-through latency at all doses in comparison with vehicle group, but there is no difference as compared to morphine-treated group (5 mg/kg, ip). No significant difference in retention score was also observed between 1, 5 and 10 mg/kg of mitragynine-treated groups. Results obtained suggest that acute administration of mitragynine does impair the memory formation, consolidation and retrieval of inhibitory avoidance task in rats.
Acknowledgements
This research was supported by grants from Higher Institution Centre of Excellence, Ministry of Higher Education, Malaysia.
Keywords:
Mitragyna speciosa,
mitragynine,
memory formation,
memory consolidation,
memory retrieval,
Inhibitory avoidance
Conference:
ACNS-2012 Australasian Cognitive Neuroscience Conference, Brisbane, Australia, 29 Nov - 2 Dec, 2012.
Presentation Type:
Poster Presentation
Topic:
Memory
Citation:
Suhaimi
F,
Hassan
Z,
Navaratnam
V and
Müller
CP
(2012). IMPAIRMENT OF MEMORY FORMATION, CONSOLIDATION AND RETRIEVAL OF INHIBITORY AVOIDANCE TASK IN ACUTE MITRAGYNINE-TREATED RATS.
Conference Abstract:
ACNS-2012 Australasian Cognitive Neuroscience Conference.
doi: 10.3389/conf.fnhum.2012.208.00176
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Received:
28 Sep 2012;
Published Online:
17 Nov 2012.
*
Correspondence:
Miss. Farah Wahida Suhaimi, Universiti Sains Malaysia, Centre for Drug Research, Minden, Penang, 11800, Malaysia, sfarahwahida@usm.my