The capture and suppression of irrelevant response tendencies: a TMS-DTI approach
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1
University of Amsterdam, Netherlands
Selective inhibitory control when selecting between two actions is an important aspect of goal-directed behavior. In the Simon task, participants respond to a relevant feature (circle color) while ignoring an irrelevant feature (circle location). The goal of the experiments is to link behavioral indices of top-down suppression of involuntary response impulses and response capture with physiological and anatomical markers.In three experiments we collected single pulse, repetitive Transcranial Magnetic Stimulation (spTMS and rTMS) and Diffusion Tensor Imaging (DTI) data. Behavioral data was assessed in all experiments, using RT distribution analyses and conditional accuracy functions (CAF). In the first experiment spTMS is applied over motor cortex at different timing moments to link behavioral indices of inhibition with physiological markers and to track its time course. In the second experiment DTI data was collected to link behavioral indices of inhibition with anatomical markers. In the third experiment 1hz offline rTMS was applied over the pre supplementary motor area (pre-SMA) and right inferior frontal gyrus (rIFG) to interfere with the function of the two cortical areas.The spTMS results showed an early increase in M1 activation indicative of response capture, followed by cortical inhibition on correct interference trials. DTI analyses suggested involvement of pre-SMA and rIFG. Preliminary data from the rTMS experiment point to more fast errors after pre-SMA stimulation, indicating impaired response selection. Secondly, rIFG stimulation seems to enhance interference effects, suggesting impaired selective suppression of irrelevant information.
Keywords:
decision-making,
DTI
Conference:
XI International Conference on Cognitive Neuroscience (ICON XI), Palma, Mallorca, Spain, 25 Sep - 29 Sep, 2011.
Presentation Type:
Poster Presentation
Topic:
Poster Sessions: Decision Making, Reward Processing & Response Selection
Citation:
Van Campen
D,
Van Den Wildenberg
W and
Ridderinkhof
K
(2011). The capture and suppression of irrelevant response tendencies: a TMS-DTI approach.
Conference Abstract:
XI International Conference on Cognitive Neuroscience (ICON XI).
doi: 10.3389/conf.fnhum.2011.207.00364
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Received:
23 Nov 2011;
Published Online:
28 Nov 2011.
*
Correspondence:
Dr. Dilene Van Campen, University of Amsterdam, Amsterdam, Netherlands, a.d.vancampen@uva.nl