ACE I/D polymorphism and the risk of ischemic stroke: A Sri Lankan outlook
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1
University of Sri Jayewardenepura, Genetic Diagnostic & Research Laboratory, Faculty of Medical Sciences, Sri Lanka
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2
The National Hospital of Sri Lanka, Neurology Unit, Sri Lanka
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3
Sri Jayewardenepura General Hospital, Neurology Unit, Sri Lanka
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4
Johnson & Johnson Pharmaceutical Research & Development, Department of Non Clinical Statistics, United States
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5
University of Colombo, Department of Statistics ,Faculty of Science, Sri Lanka
South Asian ethnicity confers a greater risk of ischemic stroke (IS) than European ancestry regardless of country inhabited. High risk of Angiotensin-Converting Enzyme ACE/DD (deletion) variant in South Asians which accounts for a five-fold increase in the risk of overall IS relative to Europeans has been reported. Although the genes associated with stroke in European populations have been investigated, they remain largely unknown in South Asians. The study aimed to determine the relationship between the ACE I/D polymorphism and the risk of IS in Sri Lanka. Clinically diagnosed IS patients {n= 117 [young stroke (<45yrs) n=24 (21%), male-74 (62%), female-43 (36.1%)] versus healthy controls [n=64, male-31 (48.4%), female-29 (45.3%)] were studied for the presence of ACE gene polymorphism along with risk factors such as hypertension, diabetes, myocardial infarction, hypercholesteremia and smoking. Genotypes were defined as DD, II and ID according to the presence of the D (deletion) and I (insertion) alleles. A significant association (75%, P<0.0001) found in young patients (<40yrs) having ID allele and hypertension. The frequency of the DD allele was significant among hypertensive subjects [n=25, 26.8% (p=0.041*), Male-16 (64%), Female-9 (36%)], particularly in men. ACE genotype frequency in cases (II-41.8%, ID-36.7%, DD-25.6%) and controls (II-26.6%, ID-45.3%, DD-28.1%) has a total allele frequency I>D. No significant difference in ACE allele frequencies observed between case and control group (p>0.05). In contrast to Caucasians, hypertensive patients of our cohort with ID polymorphism may have a higher risk of getting stroke at their young age. The ACE DD polymorphism in our population shows trend towards increasing risk of hypertension in respect to males.
Keywords:
Hypertension,
gene,
ischemic stroke,
polymorphism,
angiotensin-converting enzyme
Conference:
14th Meeting of the Asian-Pacific Society for Neurochemistry, Kuala Lumpur, Malaysia, 27 Aug - 30 Aug, 2016.
Presentation Type:
Poster Presentation Session
Topic:
14th Meeting of the Asian-Pacific Society for Neurochemistry
Citation:
Udawatte
NS,
Gamage
R,
Ragunathan
MK,
Fernando
H,
Kulathunga
A,
Gunasekara
H,
Wijekoon
NB,
Gonawala
BL,
Amarathunga
D,
Sooriyarachchi
MR and
De Silva
K
(2016). ACE I/D polymorphism and the risk of ischemic stroke: A Sri Lankan outlook.
Conference Abstract:
14th Meeting of the Asian-Pacific Society for Neurochemistry.
doi: 10.3389/conf.fncel.2016.36.00157
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Received:
04 Aug 2016;
Published Online:
11 Aug 2016.
*
Correspondence:
Prof. K. Ranil De Silva, University of Sri Jayewardenepura, Genetic Diagnostic & Research Laboratory, Faculty of Medical Sciences, Gangodawila, Nugegoda, Sri Lanka, ranil@sjp.ac.lk