Higher baseline tumor necrosis factor [TNF]-α and early postoperative interleukin [IL]-10 level are associated with postoperative sepsis in cardiac surgery: A preliminary study
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1
Military hospital tunis, Tunisia
Background and aim: Sepsis after cardiac surgery under cardiopulmonary bypass (CPB) is a serious complication. Cytokines are the main and first actors in sepsis(1), therefore the aim of this study was to evaluate pro-inflammatory (IL1, IL-6, IL-8 and TNF-α) and anti-inflammatory (IL-10) cytokin in patients undergoing a CPB as a precocious markers.
Methods: Patients undergoing a CPB were enrolled in a prospective clinical study. They were divided in two groups as Septic and non septic patients. The levels of TNFα,IL-6, IL-8, and IL-10 were measured at four different periods (T1: induction, T2: 5 minutes after the end of CBP , T3: 4h after the end of CBP : and T4: 24h post CBP). The CRP was measured at day 1, 3, 6 and 9 after surgery.
Results: Nineteen patients were studied. Six patients presented a postoperative sepsis. Only TNF-α at T1 [266.5 UI/ml (9.93; 480) vs. 7.75 UI/ml (6.66; 11.35) in septic vs. non septic patients respectively; p= 0.041] and IL-10 at T3 [6.35 UI/ml (5.37; 6.89) vs. 5 UI/ml (5; 5.01) in septic vs. non septic patients respectively; p= 0.022] were found to be associated with postoperative sepsis.Quantitative variables are expressed as median (Interquartile range). There was no significant difference among CRP measurements.
Conclusion: Monitoring of cytokines, mainly TNFα and IL-10, are more reliable markers then CRP in this procedure. Therefore, these cytokines might be a new tools for management of sepsis during CPB.However the sample size in this preliminary study was too small to allow any definitive conclusion.
References
- Adib-Conquy, M and Cavaillon, J-M. Host inflammatory and anti-inflammatory response during sepsis. Pathologie Biologie. 60 (2012), 306–313.
Keywords:
Sepsis,
Inflammation,
Cytokines,
cardiopulmonarybypass,
interleukin10,
Tumor Necrosis Factor-alpha
Conference:
15th International Congress of Immunology (ICI), Milan, Italy, 22 Aug - 27 Aug, 2013.
Presentation Type:
Abstract
Topic:
Innate immunity
Citation:
Mouna
B,
Riheb
A,
Chiheb
R,
Walid
G,
Soumaia
H,
Iheb
I,
Chama
K,
Slim
S,
Mustapha
F and
Ezzedine
G
(2013). Higher baseline tumor necrosis factor [TNF]-α and early postoperative interleukin [IL]-10 level are associated with postoperative sepsis in cardiac surgery: A preliminary study
.
Front. Immunol.
Conference Abstract:
15th International Congress of Immunology (ICI).
doi: 10.3389/conf.fimmu.2013.02.01163
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Received:
15 Jul 2013;
Published Online:
22 Aug 2013.
*
Correspondence:
Dr. Ben Azaiz Mouna, Military hospital tunis, tunis, Tunisia, drmouna1@yahoo.fr