The role of follicular helper T cells in mycobacterial infection
-
1
National Institute of Infectious Disease, Japan
-
2
National Sanatorium Tama-Zensyouen, Japan
-
3
The Walter and Eliza Hall Institute of Medical Research, Australia
Immunological protection against Mycobacterial infection requires the
activation of the cellular arm of the immune response. However, the role
of humoral immunity against Mycobacterial infection is not well
understood until now. Follicular helper T (Tfh) cells are one of CD4+
helper T cell subsets that regulate humoral immunity through B cell
mediated antibody secretion. IL-21 secreted by Tfh cells plays an
important role of induction of the humoral immunity. It is however less
clear whether Tfh cells participate cellular immunity. To investigate
the role of Tfh cells in mycobacterial infection, we focused on the
induction and differentiation of Tfh cells. We used Mycobacterium bovis
BCG (Bacille de Calmette et Guérin) that is a popular vaccine against
Mycobacterial tuberculosis. Using our recently reported IL-21-GFP
reporter mouse, we have compared the frequency, phenotype and capacity
to produce IL-21 from Tfh cells in both lymphoid and non-lymphoid organs
following BCG and influenza virus infection.
Acknowledgements
This work was supported in part by a Grant-in-Aid for Research on Emerging and Re-emerging Infectious Diseases from the Ministry of Health, Labour, and Welfare of Japan.
Keywords:
Follicular helper T cells,
IL-21,
BCG,
Influenza A virus,
humoral immunity,
Cellular immunity
Conference:
15th International Congress of Immunology (ICI), Milan, Italy, 22 Aug - 27 Aug, 2013.
Presentation Type:
Abstract
Topic:
Adaptive Immunity
Citation:
Shimohakamada
Y,
Tamura
T,
Makino
M and
Nutt
S
(2013). The role of follicular helper T cells in mycobacterial infection.
Front. Immunol.
Conference Abstract:
15th International Congress of Immunology (ICI).
doi: 10.3389/conf.fimmu.2013.02.00988
Copyright:
The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers.
They are made available through the Frontiers publishing platform as a service to conference organizers and presenters.
The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated.
Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed.
For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions.
Received:
28 Jun 2013;
Published Online:
22 Aug 2013.
*
Correspondence:
Dr. Yoko Shimohakamada, National Institute of Infectious Disease, Higashimuayama, Japan, ssdd@niid.go.jp