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Clinical Relevance of HLA and MICA Antibodies in Live Related Renal Transplantation

Deepali K. Bhat1, Jamshaid A. Siddiqui1, Sanjeev Goswami1, Ajay K. Baranwal1, Gurvinder Kaur1, Sanjay K. Agarwal1 and Narinder K. Mehra1*
  • 1 All India Institute of Medical Sciences, Transplant Immunology & Immunogenetics, India

The presence of HLA and non-HLA antibodies has been associated with rejection and poor allograft outcome following renal transplantation. The present study was undertaken to evaluate the clinical role of HLA and MICA antibodies in live related renal transplantation. Sera from 64 renal transplant patients before and after 7-14 days post transplantation were taken and analysed by Luminex XY platform for the presence of HLA and MICA antibodies. Presence of both of these antibodies correlated with poor graft survival. A comparison of well functioning grafts (WFG) with the rejection cases in the presence/ absence of all the three types of antibodies was done. The 30% of the acute rejection cases had all the three types (HLA Class I, II and MICA) of antibodies present at the pre-transplant stage. However, none of the well functioning graft showed the presence of all the three types (P<0.001). 10% of the acute rejection cases showed de novo development of HLA antibodies. On the other hand 50% of the ATN cases showed the presence of all the three types of antibodies (P<0.0001). Interestingly, 33% of the cases which developed ATN were detected to have no HLA class I or HLA class II antibodies but anti-MICA antibodies in both pre and post transplant serum samples. Although 5% of the patients with WFG showed the presence of HLA class I and class II antibodies none were detected to have the pre-transplant or post-transplant MICA antibodies. The study highlights the relevance of MICA antibodies in poor graft survival.

Keywords: Renal, MICA antibodies, HLA, Graft Rejection, Graft Survival

Conference: 15th International Congress of Immunology (ICI), Milan, Italy, 22 Aug - 27 Aug, 2013.

Presentation Type: Abstract

Topic: Translational immunology and immune intervention

Citation: Bhat DK, Siddiqui JA, Goswami S, Baranwal AK, Kaur G, Agarwal SK and Mehra NK (2013). Clinical Relevance of HLA and MICA Antibodies in Live Related Renal Transplantation. Front. Immunol. Conference Abstract: 15th International Congress of Immunology (ICI). doi: 10.3389/conf.fimmu.2013.02.00806

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Received: 21 Jun 2013; Published Online: 22 Aug 2013.

* Correspondence: Prof. Narinder K Mehra, All India Institute of Medical Sciences, Transplant Immunology & Immunogenetics, New Delhi, Delhi, 110029, India, narin.mehra@gmail.com