HLA-G6 and reproductive immunology
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1
mazandaran univesity of medical science, Iran
Background: The definite cause of several pathologies of pregnancy including reproductive failure is still unknown. HLA-G6, a non classical class Ib HLA, is novel molecule in the tolerance between fetus and mother. The purpose of this study was evaluation of HLA-G6 soluble isoforms and also difference in total expression of these antigens in threatened miscarriage pregnant women termination to reproductive failure in comparison with control group.
Materials & Methods: The study sample enrolled 101 threatened miscarriage pregnant women in age of 20-32Y in first trimester without any physiological or genetic disorders related to reproductive failure as cases and 101 women with normal pregnancy by history of term pregnancy and no miscarriage as controls. We evaluated expression of HLA-G6 soluble isoforms on PBMCs by Real-time PCR.
Results: The results showed the significant decrease in expression level of HLA-G6 isofrms in threatened miscarriage pregnant women in comparison with controls (p < 0.05).
Conclusion: The different concentration of HLA-G6 molecule is necessary for saving of pregnancy. Therefore, It is concluded that HLA-G6 is an important molecule as predictive marker in early stages of reproductive failure for setting a clinical test.
Keywords:
HLA-G6,
reproductive immunology,
non classical HLA,
miscarriage,
Real-Time PCR
Conference:
15th International Congress of Immunology (ICI), Milan, Italy, 22 Aug - 27 Aug, 2013.
Presentation Type:
Abstract
Topic:
Adaptive Immunity
Citation:
Farzad
F and
Abediankenari
S
(2013). HLA-G6 and reproductive immunology.
Front. Immunol.
Conference Abstract:
15th International Congress of Immunology (ICI).
doi: 10.3389/conf.fimmu.2013.02.00468
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Received:
15 Apr 2013;
Published Online:
22 Aug 2013.
*
Correspondence:
Dr. Saeed Abediankenari, mazandaran univesity of medical science, Sari, Iran, abedianlab@yahoo.co.uk