Metformin modulates lipolysis and inflammation through the modulation of T cell priming in obese-induced Type II diabetic mice
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1
Sahmyook University, Republic of Korea
Inflammation is regarded as a key process underlying metabolic diseases in obese individuals where adipose tissue shows features characteristic of active local inflammation. Metformin is used for treating of T2D and have been suggested that metformin has anti-inflammatory properties. This study investigated the therapeutic effect of metformin on diabetic symptoms in DIO mice. Here we show metformin attenuates metabolic disorder in DIO mice and suppresses MHC-restricted antigen presentation in DCs. Metformin decreased aipogenesis related genes, FAS, SCD-1, GPAT, SREBP1a, and lipases, LPL, ATGL, HSL, but also suppressed innate cytokines expression through APPL1-AMPK-sirt1 signaling. Metformin decreased both class I- and class II-restricted presentation of exogenous OVA in DCs. Metformin also decreased expression of the co-stimulatory molecules, ICAM-1 and B7-1/-2, and MHC class I and II molecules but not phagocytic activity. Metformin decreased MHC class II-restricted exogenous antigen presentation in peritoneal macrophages in vivo. These results show that metformin attenuates adipogenesis and suppresses immune responses through APPL1-AMPK-sirt1-NF-κB signaling and followed by decreases MHC-restricted presentation of exogenous antigen. Theses finding suggests that modulation of the antigen presentation pathway by metformin could provide a novel means for regulating T cell responses in terms of controlling of inflammation in metabolic diseases.
Keywords:
Metformin,
Lipolysis,
Inflammation,
Dendritic Cells,
Antigen Presentation
Conference:
15th International Congress of Immunology (ICI), Milan, Italy, 22 Aug - 27 Aug, 2013.
Presentation Type:
Abstract
Topic:
Immune-mediated disease pathogenesis
Citation:
Shin
S,
Hyun
B,
Lee
A,
Lee
S,
Kong
H,
Han
S,
Song
Y and
Kim
K
(2013). Metformin modulates lipolysis and inflammation through the modulation of T cell priming in obese-induced Type II diabetic mice.
Front. Immunol.
Conference Abstract:
15th International Congress of Immunology (ICI).
doi: 10.3389/conf.fimmu.2013.02.00185
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Received:
11 Mar 2013;
Published Online:
22 Aug 2013.
*
Correspondence:
Prof. Kyungjae Kim, Sahmyook University, Seoul, Republic of Korea, kinkj@syu.ac.kr